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Cholesterol and PI(4,5)P2 in Vital Biological Functions From Coexistence to Crosstalk /

Cholesterol is an essential component of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), although a minor phospholipid, is the most abundant membrane phosphoinositide. Both lipids play key roles in a variety of cellular functions including as signalling molecules and major re...

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Dettagli Bibliografici
Ente Autore: SpringerLink (Online service)
Altri autori: Dantsker, Avia Rosenhouse- (Redattore)
Natura: Elettronico eBook
Lingua:inglese
Pubblicazione: Cham : Springer International Publishing : Imprint: Springer, 2023.
Edizione:1st ed. 2023.
Serie:Advances in Experimental Medicine and Biology, 1422
Soggetti:
Physical biochemistry.
Lipids.
Biochemistry.
Proteins.
Biophysical Chemistry.
Lipidology.
Accesso online:https://doi.org/10.1007/978-3-031-21547-6
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Sommario:
  • Preface
  • 1. Mutual influence of cholesterol and PI(4,5)P2 on their levels
  • Chapter 1. Mechanism of the regulation of plasma cholesterol levels by PI(4,5)P2
  • Chapter 2. Effect of cholesterol depletion on ciliary PI(4,5)P2 levels
  • Chapter 3. Impact of cholesterol on PI(4,5)P2 levels in the brain
  • Chapter 4. Alterations in PIP2 levels in the intracellular cholesterol trafficking disorder NPC1
  • Chapter 5. Targeting cholesterol release and PI(4,5)P2 redistribution by the oral drug Miltefosine
  • 2. Cross-talk between cholesterol and PI(4,5)P2 as a factor affecting protein function
  • A. Plasma membrane ion channels
  • Chapter 6. From cross-talk to synergism: the combined effect of cholesterol and PI(4,5)P2 on inwardly rectifying potassium channels
  • Chapter 7. Link between lysosomal cholesterol and PI(4,5)P2 in the regulation of the voltage gated KCNQ2/3 potassium channel
  • Chapter 8. Cholesterol and PI(4,5)P2 binding to a ciliary membrane transient receptor potential channel
  • Chapter 9. Regulation of ell by cholesterol and PI(4,5)P2
  • Chapter 10. Cholesterol stimulates the epithelial sodium channel in a PI(4,5)P2-dependent manner
  • Chapter 11. Roles of cholesterol and PI(4,5)P2 in store operated calcium entry
  • Chapter 12. Roles of cholesterol and PI(4,5)P2 levels in the modulation of the calcium activated chloride channel TMEM16A
  • B. Lipid transport proteins--Chapter 13. PI(4,5)P2 facilitates ORP1-mediated cholesterol transport by promoting membrane targeting and cholesterol extraction
  • Chapter 14. Role of PI(4,5)P2 binding in ORP2-mediated cholesterol distribution
  • Chapter 15. PI(4,5)P2-dependent transport of cholesterol from lysosomes to peroxisomes at lysosomeperoxisome contact sites
  • 3. Cellular processes at the intersection of cholesterol and PI(4,5)P2 involvement
  • Chapter 16. The insertion of the N-terminal domain of Gasdermin-D is increased byPI(4,5)P2 and decreased by cholesterol
  • Chapter 17. Cholesterol promotes the cooperative interaction of formins with PI(4,5)P2 to initiate actin nucleation
  • Chapter 18. Cooperation between cholesterol and PI(4,5)P2 in the regulation of Engrailed-2 homeoprotein intercellular trafficking
  • Chapter 19. Cholesterol and PI(4,5)P2 as a membrane nanoplatform for HIV assembly
  • Chapter 20. Role of Cholesterol and PI(4,5)P2 in the localization of the HIV-1 structural polyprotein Gag to the plasma membrane.

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