Integrins in Health and Disease Key Effectors of Cell-Matrix and Cell-Cell Interactions /
Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth...
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| Other Authors: | , |
| Format: | Electronic eBook |
| Language: | English |
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Cham :
Springer International Publishing : Imprint: Springer,
2023.
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| Edition: | 1st ed. 2023. |
| Series: | Biology of Extracellular Matrix,
13 |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-3-031-23781-2 |
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| 245 | 1 | 0 | |a Integrins in Health and Disease |h [electronic resource] : |b Key Effectors of Cell-Matrix and Cell-Cell Interactions / |c edited by Donald Gullberg, Johannes A. Eble. |
| 250 | |a 1st ed. 2023. | ||
| 264 | 1 | |a Cham : |b Springer International Publishing : |b Imprint: Springer, |c 2023. | |
| 300 | |a XII, 472 p. 1 illus. |b online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 341 | 0 | |b Table of contents navigation |2 onix | |
| 341 | 0 | |b Single logical reading order |2 onix | |
| 341 | 0 | |b Short alternative textual descriptions |2 onix | |
| 341 | 0 | |b Use of color is not sole means of conveying information |2 onix | |
| 341 | 0 | |b Use of high contrast between text and background color |2 onix | |
| 341 | 0 | |b Next / Previous structural navigation |2 onix | |
| 341 | 0 | |b All non-decorative content supports reading without sight |2 onix | |
| 347 | |a text file |b PDF |2 rda | ||
| 490 | 1 | |a Biology of Extracellular Matrix, |x 2191-1959 ; |v 13 | |
| 505 | 0 | |a Part 1: Knockouts and animal models -- Integrins α1β1 and α2β1 – The generalist collagen receptors -- Roles for Integrin α3β1 in Development and Disease -- Part 2: Fibrosis& Cancer -- Integrins: Key targets in tissue fibrosis and tumor stroma -- Integrins in Cardiac Form, Function and Disease -- Integrin 8 and its ligand nephronectin in health and disease -- v integrin-dependent TGF activation in cancer: a brief update -- Part 3: Human disease -- a11b1, a mesenchymal collagen-binding integrin with a central role in tissue- and tumor fibrosis -- Integrins in pathological tissue remodelling of joints -- α4 integrins in immune homeostasis and disease -- β2-integrins in immunity: new roles for old players -- Structure and function of the leukocyte integrin αMβ2 -- Part 4: Integrins in hemostasis, and immune control -- Platelet integrins: Critical mediators of haemostasis and pathological thrombus formation -- Integrins as receptors for bacterial and viral pathogens. | |
| 520 | |a Integrins are heterodimeric cell surface receptors which anchor cells to different extracellular matrix proteins or act as cell-cell receptors. They play pivotal roles not only across a wide range of physiological processes including tissue morphogenesis, wound healing, and regulation of cell growth, but also in numerous pathological conditions such as autoimmunity, infectious disease, and carcinogenesis. This book aims to provide readers a summary of the most important integrins and their respective biological functions. Readers will learn about knockout- and animal models to study the functionality of key collagen-, laminin-, and nephronectin-binding integrins. Additionally, the role of integrins in pathological tissue remodeling in joints and in developing and diseased cardiac tissue are discussed. Reviews of the current knowledge of the role of integrins in tissue and tumor fibrosis, angiogenesis and tumor progression are an important part of this work. Finally, the book discusses integrins in the context of the immune system, how to target integrin-ligand interactions with antibodies, and the role of integrins as receptors for bacterial and viral cell invasion. Both experienced researchers and clinicians, as well as PhD students who wish to study the extracellular matrix and cell adhesion molecules will find “Integrins in Health and Disease - Key Effectors of Cell-Matrix and Cell-Cell Interactions” authoritative, easily accessible, and vastly informative. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology. | ||
| 532 | 8 | |a Accessibility summary: This PDF does not fully comply with PDF/UA standards, but does feature limited screen reader support, described non-text content (images, graphs), bookmarks for easy navigation and searchable, selectable text. Users of assistive technologies may experience difficulty navigating or interpreting content in this document. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com. | |
| 532 | 8 | |a No reading system accessibility options actively disabled | |
| 532 | 8 | |a Publisher contact for further accessibility information: accessibilitysupport@springernature.com | |
| 650 | 0 | |a Cell adhesion. | |
| 650 | 0 | |a Cytology. | |
| 650 | 0 | |a Proteins . | |
| 650 | 1 | 4 | |a Cell Adhesion. |
| 650 | 2 | 4 | |a Cell Biology. |
| 650 | 2 | 4 | |a Protein Biochemistry. |
| 700 | 1 | |a Gullberg, Donald. |e editor. |0 (orcid)0000-0002-7245-4437 |1 https://orcid.org/0000-0002-7245-4437 |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Eble, Johannes A. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9783031237805 |
| 776 | 0 | 8 | |i Printed edition: |z 9783031237829 |
| 776 | 0 | 8 | |i Printed edition: |z 9783031237836 |
| 830 | 0 | |a Biology of Extracellular Matrix, |x 2191-1959 ; |v 13 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-031-23781-2 |
| 912 | |a ZDB-2-SBL | ||
| 912 | |a ZDB-2-SXB | ||
| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||