Trials for Cerebellar Ataxias From Cellular Models to Human Therapies /
Despite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the p...
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| Kolejni autorzy: | , , , |
| Format: | Elektroniczne E-book |
| Język: | angielski |
| Wydane: |
Cham :
Springer International Publishing : Imprint: Springer,
2023.
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| Wydanie: | 1st ed. 2023. |
| Seria: | Contemporary Clinical Neuroscience,
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| Hasła przedmiotowe: | |
| Dostęp online: | https://doi.org/10.1007/978-3-031-24345-5 |
| Etykiety: |
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Spis treści:
- Part I: Basic Science of Cerebellum and Ataxias
- Functional anatomy of the cerebellum
- Cerebellar physiology
- Cerebellar biochemistry/pharmacology
- Genetics of dominant ataxias
- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics
- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches
- Ion Channel Genes and Ataxia
- Part II: Biomarkers and tools of trials
- How to Design a Therapeutic Trial in SCAs
- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers
- Clinical rating scales for ataxia
- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding
- Cerebellar learning in the prism adaptation task
- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias
- Part III: Autosomal Dominant Cerebellar Ataxias
- Riluzole in progressive cerebellar ataxias
- ASOs against ATXN2 in preclinical and phase 1 trials
- Antisense oligonucleotide therapy against SCA3
- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities
- Experimental neurotransplantation for cerebellar ataxias
- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside
- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia
- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias
- Physical therapy in Cerebellar Ataxia
- Part IV: Autosomal Recessive Cerebellar Ataxias
- Recent advances on therapeutic approaches for Friedreich’s Ataxia
- Therapeutic use of interferon gamma in Friedreich ataxia
- Metabolic treatments of cerebellar ataxia
- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome
- Part V: Sporadic Ataxias
- Therapeutic strategies inimmune-mediated cerebellar ataxias
- Coenzyme Q10 in MSA
- State of the Art and History of Therapeutics in Ataxias.