Evolutionary Dynamics of Malignancy The Genetic and Environmental Causes of Cancer /
Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian s...
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| Tác giả chính: | |
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| Tác giả của công ty: | |
| Định dạng: | Điện tử eBook |
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
Cham :
Springer International Publishing : Imprint: Springer,
2023.
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| Phiên bản: | 1st ed. 2023. |
| Những chủ đề: | |
| Truy cập trực tuyến: | https://doi.org/10.1007/978-3-031-32573-1 |
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Mục lục:
- Chapter 1: Cancer as a Disease of Cell Proliferation
- Chapter 2: Genetic and Chromosomal Instability
- Chapter 3: Cancer as a Disease of Defective Cell Cycle Checkpoint Function
- Chapter 4: The DNA Damage Checkpoint
- Chapter 5: Dynamics of the Spindle Assembly Checkpoint
- Chapter 6: Cancer as a Disease of Complexity: The Dynamics of Drug Resistance
- Chapter 7: Chronic Myeloid Leukaemia: a One-Hit Malignancy
- Chapter 8: Chronic Myelomonocytic Leukaemia: a Three-Hit Malignancy
- Chapter 9: The Cancer Stem Cell and Tumour Progression
- Chapter 10: Evading the antitumour immune response
- Chapter 11: Implications of Evolutionary Dynamics for Cancer Treatment and Prevention
- Chapter 12: In science, all conclusions are provisional.