Human iPSC-derived Disease Models for Drug Discovery
Since their development a decade ago, human induced pluripotent stem cells (iPSC) have revolutionized the study of human disease, given rise to regenerative medicine technologies, and provided exceptional opportunities for pharmacologic research. These cells provide an essentially unlimited supply o...
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| Autres auteurs: | , |
| Format: | Électronique eBook |
| Langue: | anglais |
| Publié: |
Cham :
Springer International Publishing : Imprint: Springer,
2023.
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| Édition: | 1st ed. 2023. |
| Collection: | Handbook of Experimental Pharmacology,
281 |
| Sujets: | |
| Accès en ligne: | https://doi.org/10.1007/978-3-031-42349-9 |
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Table des matières:
- Part 1 General considerations
- Human iPS for clinical applications and cellular products
- 3D-printed iPS disease models
- Part 2 CNS iPSC and organoids
- iPS-derived neurons and brain organoids from patients (brain)
- iPS-derived RGCs (eye)
- iPS-derived glia (brain)
- iPSC to model blood-brain barrier endothelial cells
- Part 3 iPSC-derived nociceptive neurons
- IPSC-based peripheral nerve modeling
- Part 4 Non-neuronal specialized cell types
- iPSC-based drug screening of differentiated cardiomyocyte subtypes
- iPSC-based cardiac disease modeling: from cell to tissue
- iPSC-derived corneal endothelial cell
- iPSC-derived trabecular meshwork (eye)
- iPSC for in vitro disease modeling of diabetes.