Microglia Physiology, Pathophysiology and Therapeutic Potential /

The past decade has witnessed a revolution in our understanding of microglia, especially since their roles in the healthy CNS have started to unravel. These cells were shown to actively maintain health, in concert with neurons and other types of CNS cells, providing further insight into their crucia...

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書誌詳細
団体著者:	SpringerLink (Online service)
その他の著者:	Tremblay, Marie-Ève (編集者), Verkhratsky, Alexei (編集者)
フォーマット:	電子媒体 eBook
言語:	英語
出版事項:	Cham : Springer International Publishing : Imprint: Springer, 2024.
版:	1st ed. 2024.
シリーズ:	Advances in Neurobiology, 37
主題:	Neurosciences. Neurology . Immunology. Neuroscience. Neurology.
オンライン･アクセス:	https://doi.org/10.1007/978-3-031-55529-9
タグ:	タグ追加タグなし, このレコードへの初めてのタグを付けませんか!

目次:

PART I: Introduction
Chapter 1: General Pathophysiology of Microglia
Chapter 2: History of Microglia
Chapter 3: Evolution of Microglia
Chapter 4: Visualization, Fate Mapping, Ablation and Mutagenesis of Microglia in the Mouse Brain
Chapter 5: Technological Innovations: Progress of the Structural and Functional in vivo Imaging of Microglia
PART II: Basic Discoveries in Physiology
Chapter 6:Microglial Physiology: Receptors
Chapter 7: Microglial Physiology: Calcium Signalling
Chapter 8:Contactomics of Microglia and Intercellular Communication
Chapter 9: Elimination of Neurones: Embryonic and Postnatal Development
Chapter 10: Developmental Angiogenesis, Astrogliogenesis, and Myelination
Chapter 11: Synaptic Formation and Elimination
Chapter 12: Synaptic Maturation, Activity, and Plasticity
Chapter 13: Adult Neurogenesis, Learning and Memory
Chapter 14: Regulation of Sleep and Wakefulness
PART III: General Pathophysiology of Microglia
Chapter 15: Roles in Innate Immunity
Chapter 16: Microglia and Systemic Immunity
Chapter 17: Microglia and Microbiome-Gut-Brain Axis
Chapter 18: Stress and Microglia: A Double-Edged Relationship
Chapter 19: Substance Use and Addiction
Chapter 20: Microglia and Sleep Disorders
Chapter 21: Ageing
Part IV: Microglia and Pathophysiology of Diseases of Nervous System
Chapter 22: Neuropathic Pain
Chapter 23: Role of Microglia in Stroke
Chapter 24: Infectious Diseases including COVID-19 and HAND
Chapter 25: Microglia and Multiple Sclerosis
Chapter 26: Neurodevelopmental and Neuropsychiatric Disorders
Chapter 27: Neurodegenerative Diseases
Chapter 28: Microglia in Glioma
PART V: Clinical Potential
Chapter 29: Microglial Risk Alleles for Neurodegenerative Diseases (GWAS studies)
Chapter 30: Emerging Models for the Study of Human Microglia in vitro (e.g. IPSCs, minibrains)
Chapter 31: Emerging Models for the Study of Human Microglia ex vivo (comparison between human and rodent microglia)
Chapter 32: Radiotracers for Microglial PET Imaging in vivo (focus on TSPO and its limitations)
Chapter 33: Role of Microglial Modulation in Therapies for Perinatal Brain Injuries Leading to Neurodevelopmental Disorders
Chapter 34: Metabolic Control of Microglial Function
Chapter 35: Microglial Emerging Therapies and Targets under Clinical Trial
Chapter 36: Epilogue.

Microglia Physiology, Pathophysiology and Therapeutic Potential /

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