Epigenetic Mechanisms in Breast Cancer Therapy and Resistance
Epigenetic mechanisms are essential for normal mammalian development and maintenance of gene expression patterns. Disruption of epigenetic processes can lead to altered transcriptional regulation, gene levels, and malignant cellular transformation. Global alterations of the epigenetic landscape are...
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| Format: | Elektronički e-knjiga |
| Jezik: | engleski |
| Izdano: |
Cham :
Springer Nature Switzerland : Imprint: Springer,
2024.
|
| Izdanje: | 1st ed. 2024. |
| Serija: | Advances in Experimental Medicine and Biology,
1465 |
| Teme: | |
| Online pristup: | https://doi.org/10.1007/978-3-031-66686-5 |
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| 245 | 1 | 0 | |a Epigenetic Mechanisms in Breast Cancer Therapy and Resistance |h [electronic resource] / |c edited by Sanchita Bhatnagar. |
| 250 | |a 1st ed. 2024. | ||
| 264 | 1 | |a Cham : |b Springer Nature Switzerland : |b Imprint: Springer, |c 2024. | |
| 300 | |a V, 106 p. 24 illus., 23 illus. in color. |b online resource. | ||
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| 490 | 1 | |a Advances in Experimental Medicine and Biology, |x 2214-8019 ; |v 1465 | |
| 505 | 0 | |a Chapter 1 - MDIG in breast cancer progression and metastasis -- Chapter 2 - Tumor Microenvironment and Epigenetic Implications in Breast Cancer Progression -- Chapter 3 - The Epigenetic Landscape of Breast Cancer, Metabolism, and Obesity -- Chapter 4 - Epigenetic Modulations by Microbiome in Breast Cancer -- Chapter 5 - Facilitates chromatin transcription in breast and other cancers -- Chapter 6 - Advances in epigenetic therapeutics for breast cancer -- Chapter 7 - Detection methods for epigenetic mechanisms in breast cancer. | |
| 520 | |a Epigenetic mechanisms are essential for normal mammalian development and maintenance of gene expression patterns. Disruption of epigenetic processes can lead to altered transcriptional regulation, gene levels, and malignant cellular transformation. Global alterations of the epigenetic landscape are a hallmark of tumorigenesis and metastasis. Conventionally, cancer was thought to be a genetic disease, but recent advancement in the field identified an abundance of epigenetic abnormalities along with genetic alterations. The extensive reprogramming of epigenetic machinery in cancer includes DNA methylation, histone modifications, nucleosome positioning and non-coding RNAs, specifically microRNA expression. Additionally, the reversible nature of epigenetic aberrations has led to the emergence of the promising field of epigenetic therapy, and recent FDA approval of epigenetic drugs for cancer treatment. This book focuses on the epigenetic mechanisms in breast cancertherapy and resistance. It is organized into three sections, including epigenetic mechanisms in breast cancer, targeting epigenetic mechanisms for new therapies, and new and emerging methodologies to study epigenetic alterations in breast cancer. Chapters highlight various epigenetic regulations that prevent breast cancer growth and progression, as well as epigenetic alterations that contribute to breast cancer progression. This text is a useful methodology book for researchers and students interested in epigenetics in breast cancer and the fundamentals of cancer biology. | ||
| 532 | 8 | |a Accessibility summary: This PDF does not fully comply with PDF/UA standards, but does feature limited screen reader support, described non-text content (images, graphs), bookmarks for easy navigation and searchable, selectable text. Users of assistive technologies may experience difficulty navigating or interpreting content in this document. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com. | |
| 532 | 8 | |a No reading system accessibility options actively disabled | |
| 532 | 8 | |a Publisher contact for further accessibility information: accessibilitysupport@springernature.com | |
| 650 | 0 | |a Cancer |x Genetic aspects. | |
| 650 | 0 | |a Epigenetics. | |
| 650 | 0 | |a Cancer |x Treatment. | |
| 650 | 0 | |a Medical microbiology. | |
| 650 | 1 | 4 | |a Cancer Genetics and Genomics. |
| 650 | 2 | 4 | |a Epigenetics. |
| 650 | 2 | 4 | |a Cancer Therapy. |
| 650 | 2 | 4 | |a Medical Microbiology. |
| 700 | 1 | |a Bhatnagar, Sanchita. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
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| 830 | 0 | |a Advances in Experimental Medicine and Biology, |x 2214-8019 ; |v 1465 | |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-3-031-66686-5 |
| 912 | |a ZDB-2-SBL | ||
| 912 | |a ZDB-2-SXB | ||
| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||