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A Guide to Breast Cancer Research From Cellular Heterogeneity and Molecular Mechanisms to Therapy /

The book presents key topics at the forefront in breast development and cancer research in chapters authored by leading scientists in the field. The chapters provide a basis for understanding major concepts, model systems, cells of origin and heterogeneity in human breast development and cancer. The...

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Korporativní autor: SpringerLink (Online service)
Další autoři: Sørlie, Therese (Editor), Clarke, Robert B. (Editor)
Médium: Elektronický zdroj E-kniha
Jazyk:angličtina
Vydáno: Cham : Springer Nature Switzerland : Imprint: Springer, 2025.
Vydání:1st ed. 2025.
Edice:Advances in Experimental Medicine and Biology, 1464
Témata:
Cancer.
Oncology.
Cancer > Treatment.
Metastasis.
Tumors > Immunological aspects.
Cancer Biology.
Cancer Therapy.
Tumour Immunology.
On-line přístup:https://doi.org/10.1007/978-3-031-70875-6
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Obsah:
  • Part I: Development and cancer: basic concepts
  • Chapter 1: Introductory chapter by Sorlie and Clarke
  • Chapter 2: Embryonic mammary gland morphogenesis
  • Chapter 3: Breast morphogenesis: from normal development to cancer
  • Chapter 4: Single-Cell Analysis in the Mouse and Human Mammary Gland
  • Part II: Development and cancer: model systems and approaches
  • Chapter 5: Recording lineage history with cellular barcodes in the mammary epithelium and in breast cancer
  • Chapter 6: Models for studying ductal carcinoma in situ progression
  • Chapter 7: Patient-derived xenografts of breast cancer
  • Chapter 8: Rat Models of Breast Cancer
  • Part III: Development and cancer: cells of origin and heterogeneity
  • Chapter 9: Cells of origin of breast cancer and intertumoral heterogeneity
  • Chapter 10: Mechanisms of regulation of cell fate in breast development and cancer
  • Chapter 11: Classification of breast cancer through the perspective of cell identity models
  • Part IV: Cellular and molecular basis
  • Chapter 12: The Microenvironment in DCIS and its Role in Disease Progression
  • Chapter 13: Molecular basis of breast tumor heterogeneity
  • Chapter 14: E-cadherin-mediated cell-cell adhesion and invasive lobular breast cancer
  • Part V: Signalling pathways
  • Chapter 15: Hormone signaling in breast development and cancer
  • Chapter 16: RANK/RANKL signaling pathway in breast development and cancer
  • Chapter 17: Metabolic Reprogramming and Adaption in Breast Cancer Progression and Metastasis
  • Part VI: Metastasis and immunity
  • Chapter 18: Microenvironmental regulation of dormancy in breast cancer metastasis: “An ally that changes allegiances”
  • Chapter 19: The Roles of Myeloid Cells in Breast Cancer Progression
  • Chapter 20: Immune microenvironment in breast cancer metastasis
  • Part VII: Subtypes, treatment and resistance
  • Chapter 21: Clinical Implications of Breast Cancer Intrinsic Subtypes
  • Chapter 22: Targeting Estrogen Receptor signalling in breast cancer therapy
  • Chapter 23: CDK4/6 inhibitor resistance in ER+ breast cancer
  • Chapter 24: HER2-positive breast cancer treatment and resistance.

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