Retinal Degenerative Diseases XX Mechanisms and Experimental Therapy /
This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke and presented posters at the meeting contributed to this volume. Most blinding [CG1] diseases of inherited retinal degenerations have no treatments, and age-related...
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| その他の著者: | , , , , , |
| フォーマット: | 電子媒体 eBook |
| 言語: | 英語 |
| 出版事項: |
Cham :
Springer Nature Switzerland : Imprint: Springer,
2025.
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| 版: | 1st ed. 2025. |
| シリーズ: | Advances in Experimental Medicine and Biology,
1468 |
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| オンライン･アクセス: | https://doi.org/10.1007/978-3-031-76550-6 |
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目次:
- Part I: Age-Related Macular Degeneration (AMD)
- Associations of the adaptive immune system and age-related macular degeneration
- Macrophages and and age-related macular degeneration
- RPE basal lamina biology and pathophysiology related to age-related macular degeneration
- Genotype-Phenotype Correlations and Genetic Risk Assessment in Age-Related Macular Degeneration
- Photoreceptor degeneration: more than a bystander in age-related macular degeneration
- Cellular Senescence–an emerging player in the pathogenesis of AMD
- Part II - Inherited Retinal Degenerations
- Novel Potentially Pathogenic Variants in TBC1D32 cause Non-syndromic Rod-Cone Degeneration
- The BXD32 Mouse: A High-Fidelity Model of Chronic Retinal Inflammation and Photoreceptor Degeneration
- The challenge of VUS in inherited retinal degeneration: insight from functional studies
- ABCA4 c.5461-6T>C causes Stargardt disease through exon skipping
- Assessment of ABCA4 Genetic Variants: Current Landscape and Future Prospects
- Exploring the Role of ABCA4’s ECD2 Domain in Inherited Retinal Degeneration: Computational and Functional Perspectives
- MFRP in early-onset retinal degeneration: Clinical and Molecular Perspectives
- Genetic Landscape of Non-syndromic Retinitis Pigmentosa in Portugal
- Part III: Gene Therapy and Gene Editing
- Frequency and Pattern of Gene Therapy Clinical Trials for Inherited Retinal Diseases
- CRISPR/Cas-mediated gene activation as a versatile tool for treatment of inherited retinal dystrophies
- Prime Editing Strategy to Install the RPE65 c.1430A>G Dominant Mutation
- Megabase deletion of the human EYS locus using CRISPR/Cas9
- Prime Editing Strategy to Install the Mfrp Retinal Degeneration 6 mutation
- Precise Gene Editing Technologies In Retinal Applications
- Part IV: Immunity and Inflammation
- Current perspectives of TLR2 signalling in the retina
- Monocytes in Retinal Degeneration: Little Cells with a Big Impact
- Understanding the different microglia functional states to modulate their activity in retinal degeneration
- Progress in assessing retinal microglia using single-cell RNA sequencing
- The Role of Microglia in Glaucomatous Pathology
- Part V: In-Vivo Imaging for Structure and Function
- Non-invasive assessment of ocular structure in the elderly 13-lined ground squirrel
- Part VI: Mechanisms of Degeneration
- Potential Role of NUR77 in the Aging Retinal Pigment Epithelium and Age-Related Macular Degeneration
- Identification of unexpected pathomechanisms underlying the human Usher syndrome
- The loss of Usher II proteins in mice does not affect photoreceptor ultrastructure
- A role for SARM1 in photoreceptor cell death
- Exploring Histone Modifications in Inherited Retinal Disorders
- Effect of photobiomodulation on proliferative changes in the retina: Evidence from an in vitro model of PVR
- Part VII: Mechanisms of Degeneration - Animal Models
- Calcium binding protein 4 is fundamental for retinal structure and function
- Association between C22:5-containing lipids and RPE Pathologies in Mice with Tmem135 Overexpression
- Extracellular Matrix Gene Expression Patterns in Retinal Wound Healing: A Comparative Study between Mouse and Zebrafish Laser Injury Models
- Zebrafish as a Model for Stargardt Disease
- Fish models of ageing retinal disease
- The power of zebrafish in disease modeling and therapy discovery for inherited retinal degeneration
- Unexpected retinal abnormalities in the cone-dominant northern tree shrew
- Deletion of Pnpla2 Causes Malformation and Malperformance of Mouse Photoreceptors
- Light as a mediator of acute and chronic retina degeneration
- A Knockin Model with the mouse equivalent to the c.2299delG Mutation in usherin Exhibits Early-Onset Hearing Loss and Progressive Retinal Degeneration
- Oxidative stress and energetic failure: common features and dissimilarities in 3 different mouse models of retinal pigment epithelium phagocytosis defects
- Part VIII: Mechanisms of Degeneration – Metabolism
- The connection between cellular metabolism and retinal disease
- Stimulation of Thyroid Hormone Signaling Induces Stress Responses in Mouse Retina
- Ocular Tissue-Specific Amino Acid Metabolism in Gyrate Atrophy
- Part IX: Neuroprotection
- Is Caveolin-1 required for retinal neuroprotection?
- Brain-derived neurotrophic factor in retinal integrity under diabetic and hypoxic conditions
- Part X_ Photoreceptors
- Girdin is a Class I Phosphatidylinositol 3-kinase Binding Protein in the Retina
- Photoreceptor disc morphogenesis: who are the conductors of this highly metronomic process?
- Mechanism of photoreceptor outer segment tip ingestion: Evidence of trogocytosis
- The PRPH2 D2 Loop: Biochemical Insights and Implications in Disease
- Vulnerability of the Nrl−/− Cone-Dominant Retina to Endoplasmic Reticulum Stress
- Molecular components of vesicle cycling at the rod photoreceptor ribbon synapse
- Part XI: RPE
- Less is more: the RPE cell culture medium additive THT mildly impairs RPE health
- Desmosome and Hemidesmosome Disassembly in Retinal Pigmented Epithelium – Intersection with the Exosome Pathway
- Signaling pathways in Retinal Pigment Epithelium (RPE) cells in response to stress conditions of Age-Related Macular Degeneration (AMD)
- The Importance of Differentiated RPE Cultures to Study Cell Biological Processes
- IGFBP5 as a Novel Basolateral Secretion Marker in the Retinal Pigment Epithelium
- Role of microsomal triglyceride transfer protein (MTP) in lipid processing pathways in retinal pigment epithelium
- Immunogenic switch of RPE cells
- Mitochondrial DNA Damage in the retinal pigmented epithelium (RPE) and its role in RPE pathobiology
- Part XII: Stem Cell Models and Therapies
- Live imaging microscopy of human retina organoids: Photoreceptor pathology
- The Importance of Choriocapillaris Replacement in Therapeutic Strategies for Age-Related Macular Degeneration
- Classifying Mouse RPE Morphometric Heterogeneity Using REShAPE – an AI-based Image Analysis Tool
- Dysregulation of Retinal and Photoreceptor Structural Integrity Genes in ATF6-/- Retinal Organoids
- Engineering specific human iPS reporter cell lines to generate optogenetically modified photoreceptors
- Part XIII: Retinal Cell Biology
- Phosphoinositide 3-Kinase Enhancer Protein: Insights into its Expression and Functions in Retinal Cells
- Expression of Versican in the retina and its implication in retinal disease
- The role of RPE phagocytosis in the retina metabolic ecosystem
- Ocular Localization of Complement Factor H and its Association with Diseases in the Eye
- The Role of Primary Cilia in the Eye
- Key Claudins at the Blood-Retina Barriers
- NUDC is Critical for Mitosis and Postmitotic Cell Maintenance Through its Modulation of Dynein and Actin Cytoskeletal Reorganization
- Interplay of Retinal and Choroidal Vasculatures in Ocular Health and Disease
- Genetically encoded metabolic sensors to study retina metabolism
- Riboflavin, retbindin and riboflavin transporters in the retina
- Critical Roles of SEA Domains
- Part XIV: Drug and Other Therapies
- Targeting connexins biology as therapeutic strategies against retinal diseases
- Uncovering Novel Drugs that Restore Vision Using Orthogonal Pooling in Zebrafish
- Steroid-Nitroxide Hybrid Compound Protects the Retina in a Model of CNV
- Part XV: Human Studies
- Artificial Intelligence-assisted Matching of Human Postmortem Donors to Ocular Research Projects
- Late-Onset Retinal Degeneration: clinical features and C1QTNF5/CTRP5 function.