Group Sequential and Confirmatory Adaptive Designs in Clinical Trials
This book provides an up-to-date review of the general principles and techniques of confirmatory adaptive designs, a generalization of group sequential designs. With these designs, interim analyses are performed in order to stop a trial prematurely under control of the Type I error rate. In adaptive...
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| Main Authors: | , |
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| Corporate Author: | |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cham :
Springer Nature Switzerland : Imprint: Springer,
2025.
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| Edition: | 2nd ed. 2025. |
| Series: | Springer Series in Pharmaceutical Statistics,
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| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-3-031-89669-9 |
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Table of Contents:
- Part I Group Sequential Designs
- Repeated Significance Tests Procedures with Equally Sized Stages
- Procedures with Unequally Sized Stages
- Confidence Intervals, p -Values, and Point Estimation
- Applications
- Part II Adaptive Confirmatory Designs with a Single Hypothesis: Adaptive Group Sequential Tests
- Decision Tools for Adaptive Designs
- Estimation and p-Values for Two-stage Adaptive Designs
- Adaptive Designs with Survival Data
- Part III Adaptive Designs with Multiple Hypotheses: Multiple Testing in Adaptive Designs
- Applications and Case Studies
- Appendix - Software for Adaptive Designs
- Index.