Lamins in Genome Organization and Diseases
This new book covers the molecular biology of lamins, which are nuclear-derived intermediate filament proteins that play diverse roles in nuclear homeostasis, such as conferring structural rigidity to the nucleus and holding chromosomes together. Numerous mutations in the lamin type A protein give r...
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| Altres autors: | , |
| Format: | Electrònic eBook |
| Idioma: | anglès |
| Publicat: |
Cham :
Springer Nature Switzerland : Imprint: Springer,
2025.
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| Edició: | 1st ed. 2025. |
| Col·lecció: | Subcellular Biochemistry,
115 |
| Matèries: | |
| Accés en línia: | https://doi.org/10.1007/978-3-032-00537-3 |
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| 245 | 1 | 0 | |a Lamins in Genome Organization and Diseases |h [electronic resource] / |c edited by Kaushik Sengupta, Antoine Muchir. |
| 250 | |a 1st ed. 2025. | ||
| 264 | 1 | |a Cham : |b Springer Nature Switzerland : |b Imprint: Springer, |c 2025. | |
| 300 | |a 1 online resource (X, 279 p. 30 illus.). |b 29 illus. in color. | ||
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| 490 | 1 | |a Subcellular Biochemistry, |x 2542-8810 ; |v 115 | |
| 505 | 0 | |a Chapter 1. Role of Nuclear Lamins in the Regulation of the Genome: Focus on Cardiolaminopathy -- Chapter 2. Role of Nuclear Envelope Proteins in the Structure and Function of the Neuromuscular Junction: Focus on Subsynaptic Nuclei -- Chapter 3. Tubular Lamin- and Emerin-Lined Nuclear Envelope Invaginations Isolate Chromatin Domains for Gene Expression Regulation -- Chapter 4. Laminopathies and Cancers- Involvement of Lamins and Lamin-Chromatin Interactions -- Chapter 5. Differential Expression of Lamins and Modulation of Chromatin Architecture in Carcinogenesis- tous pour un et un pour tous -- Chapter 6. Changes in Chromatin Organization and Mechanotransduction Mediated by Mutant Lamins in Laminopathies -- Chapter 7. ECM-Lamin Crosstalk in the Regulation of Genomic Stability -- Chapter 8. The Strange Case of the Noncanonical Lamina: Deep Divisions in Nuclear Organisation? -- Chapter 9. The Role of Lamins in Genome Organization: A Modelling Perspective -- Chapter 10. The Fall of the Armor: Lamin Dysregulation and a Wide Network of Laminopathies -- Chapter 11. Dynamic Post-Translational Modifications of Nuclear Lamins in Cellular Function and Pathophysiology. | |
| 520 | |a This new book covers the molecular biology of lamins, which are nuclear-derived intermediate filament proteins that play diverse roles in nuclear homeostasis, such as conferring structural rigidity to the nucleus and holding chromosomes together. Numerous mutations in the lamin type A protein give rise to a plethora of diseases called laminopathies affecting muscle, cardiac, adipose, and nervous tissues, and to a combination of all of them in the form of progeroid syndromes. Furthermore, the differential expression of lamins has been implicated in a wide variety of cancers. Over the past two decades, there has been an increasing number of interesting findings related to the perturbation of signalling cascades and transcriptome analysis in the pathogenesis of laminopathies. Few reports have also shed light on the epigenetic changes associated with these diseases. The rapid advancement of chromosome conformation capture methods has provided a new impetus to delineate the finer details of chromosome association with lamins at the topological level. Bringing together most of these exciting findings in a book that appeals to a broad readership of lamins and chromatin biology. | ||
| 532 | 8 | |a Accessibility summary: This PDF has been created in accordance with the PDF/UA-1 standard to enhance accessibility, including screen reader support, described non-text content (images, graphs), bookmarks for easy navigation, keyboard-friendly links and forms and searchable, selectable text. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com. Please note that a more accessible version of this eBook is available as ePub. | |
| 532 | 8 | |a No reading system accessibility options actively disabled | |
| 532 | 8 | |a Publisher contact for further accessibility information: accessibilitysupport@springernature.com | |
| 588 | |a Print version record. | ||
| 650 | 0 | |a Genomics. | |
| 650 | 0 | |a Cancer |x Genetic aspects. | |
| 650 | 0 | |a Biochemistry. | |
| 650 | 0 | |a Clinical biochemistry. | |
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| 650 | 2 | 4 | |a Cancer Genetics and Genomics. |
| 650 | 2 | 4 | |a Biochemistry. |
| 650 | 2 | 4 | |a Medical Biochemistry. |
| 700 | 1 | |a Sengupta, Kaushik. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Muchir, Antoine. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
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| 830 | 0 | |a Subcellular Biochemistry, |x 2542-8810 ; |v 115 | |
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