Lamins in Genome Organization and Diseases
This new book covers the molecular biology of lamins, which are nuclear-derived intermediate filament proteins that play diverse roles in nuclear homeostasis, such as conferring structural rigidity to the nucleus and holding chromosomes together. Numerous mutations in the lamin type A protein give r...
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| Format: | Elektronisch E-Book |
| Sprache: | Englisch |
| Veröffentlicht: |
Cham :
Springer Nature Switzerland : Imprint: Springer,
2025.
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| Ausgabe: | 1st ed. 2025. |
| Schriftenreihe: | Subcellular Biochemistry,
115 |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1007/978-3-032-00537-3 |
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Inhaltsangabe:
- Chapter 1. Role of Nuclear Lamins in the Regulation of the Genome: Focus on Cardiolaminopathy
- Chapter 2. Role of Nuclear Envelope Proteins in the Structure and Function of the Neuromuscular Junction: Focus on Subsynaptic Nuclei
- Chapter 3. Tubular Lamin- and Emerin-Lined Nuclear Envelope Invaginations Isolate Chromatin Domains for Gene Expression Regulation
- Chapter 4. Laminopathies and Cancers- Involvement of Lamins and Lamin-Chromatin Interactions
- Chapter 5. Differential Expression of Lamins and Modulation of Chromatin Architecture in Carcinogenesis- tous pour un et un pour tous
- Chapter 6. Changes in Chromatin Organization and Mechanotransduction Mediated by Mutant Lamins in Laminopathies
- Chapter 7. ECM-Lamin Crosstalk in the Regulation of Genomic Stability
- Chapter 8. The Strange Case of the Noncanonical Lamina: Deep Divisions in Nuclear Organisation?
- Chapter 9. The Role of Lamins in Genome Organization: A Modelling Perspective
- Chapter 10. The Fall of the Armor: Lamin Dysregulation and a Wide Network of Laminopathies
- Chapter 11. Dynamic Post-Translational Modifications of Nuclear Lamins in Cellular Function and Pathophysiology.