(Macro)Molecular Crowding Life of the Pottage /
This book presents a comprehensive overview of macromolecular crowding, a fundamental biological phenomenon that arises from the high concentration of macromolecules, such as proteins, nucleic acids, and carbohydrates, within living cells. Such crowded environment significantly reduces the amount of...
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| Formato: | Recurso Eletrônico livro eletrônico |
| Idioma: | inglês |
| Publicado em: |
Cham :
Springer Nature Switzerland : Imprint: Springer,
2025.
|
| Edição: | 1st ed. 2025. |
| coleção: | Subcellular Biochemistry,
109 |
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| Acesso em linha: | https://doi.org/10.1007/978-3-032-03370-3 |
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| 245 | 1 | 0 | |a (Macro)Molecular Crowding |h [electronic resource] : |b Life of the Pottage / |c edited by Vladimir N. Uversky. |
| 250 | |a 1st ed. 2025. | ||
| 264 | 1 | |a Cham : |b Springer Nature Switzerland : |b Imprint: Springer, |c 2025. | |
| 300 | |a 1 online resource (VI, 542 p. 82 illus.). |b 67 illus. in color. | ||
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| 490 | 1 | |a Subcellular Biochemistry, |x 2542-8810 ; |v 109 | |
| 505 | 0 | |a Chapter 1: A brief historico-philosophical overview of macromolecular crowding: Making “physiological conditions” more physiological -- Chapter 2: Effects of molecular crowding on the structural, dynamic, and functional properties of biological macromolecules: A general overview -- Chapter 3: (Macro)molecular crowding effects beyond volume exclusion -- Chapter 4: Role of aqueous media in macromolecular crowding -- Chapter 5: Effects of macromolecular crowding on the structure and dynamics of biological membranes -- Chapter 6: Effects of molecular crowding on the structure, folding, and stability of DNA -- Chapter 7: Effects of molecular crowding on the structure, folding, stability, and catalysis of RNA -- Chapter 8: Understanding the effect of macromolecular crowding on protein misfolding and aggregation -- Chapter 9: The role of macromolecular crowding in cytoskeletal organization -- Chapter 10: Macromolecular crowding in cytoplasm and cellular organelles -- Chapter 11: Macromolecular crowding in mitochondria -- Chapter 12: Molecular crowing in nuclear pore -- Chapter 13: Catalytic Droplets: Enzyme Containing Microcompartments -- Chapter 14: Macromolecular crowding in cell stress and death -- Chapter 15: Heterogeneity of molecular crowding and liquid-liquid phase separation -- Chapter 16: Reshuffling overcrowded milieu: Stress-induced reorganization of the eukaryotic membrane-less organelles -- Chapter 17: Crowding in Anhydrobiosis -- Chapter 18: Crowding and in-cell crystallization -- Chapter 19: Macromolecular crowding for reparative medicine and drug discovery applications -- Chapter 20: Simulating crowding in vitro: Not an elusive goal any longer -- Chapter 21: Molecular Crowding by Computational Approaches -- Chapter 22: Modeling Facilitated Diffusion of Proteins in Crowded Environment -- Chapter 23: The Hidden Influences of Macromolecular Crowding: A New Frontier in Cellular Biology and Medicine. | |
| 520 | |a This book presents a comprehensive overview of macromolecular crowding, a fundamental biological phenomenon that arises from the high concentration of macromolecules, such as proteins, nucleic acids, and carbohydrates, within living cells. Such crowded environment significantly reduces the amount of free water and alters key physical properties of media, such as viscosity and water activity. One of the most notable effects is volume exclusion, where the space taken up by macromolecules becomes unavailable to others, influencing molecular interactions and reaction dynamics. Cellular crowding can dramatically impact the stability and behavior of biological macromolecules, affect their folding, aggregation, and association, as well as alter the rates of chemical reactions. However, these effects are still not fully understood, largely because traditional biochemical research is conducted in dilute solutions failing to replicate the crowded conditions inside cells. To address this gap, researchers are developing experimental models that simulate macromolecular crowding and confinement, allowing for more accurate studies of biomolecular behavior under realistic conditions. These models are essential for understanding how crowding influences molecular function and cellular processes. Recent discoveries have revealed that macromolecular crowding is not uniform throughout the cell. Instead, it exhibits spatio-temporal heterogeneity, with regions of extreme crowding formed by membrane-less organelles and biological condensates—dense liquid droplets created through liquid-liquid phase separation. These dynamic structures often emerge in response to environmental changes and play critical roles in cellular organization and regulation. This book brings together leading experts to explore the foundational principles and cutting-edge developments in this field. It covers the physics of crowding, experimental techniques for characterizing these phenomena, and examples of well-understood systems. It also serves as a practical guide for researchers, helping them design experiments and generate hypotheses relevant to their study systems. Designed for both early-career scientists and those entering the field from other disciplines, this volume offers a structured and accessible introduction to macromolecular crowding. It provides curated access to essential literature and equips readers with the tools needed to navigate this complex and rapidly evolving area of research. | ||
| 532 | 8 | |a Accessibility summary: This PDF has been created in accordance with the PDF/UA-1 standard to enhance accessibility, including screen reader support, described non-text content (images, graphs), bookmarks for easy navigation, keyboard-friendly links and forms and searchable, selectable text. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com. Please note that a more accessible version of this eBook is available as ePub. | |
| 532 | 8 | |a No reading system accessibility options actively disabled | |
| 532 | 8 | |a Publisher contact for further accessibility information: accessibilitysupport@springernature.com | |
| 588 | |a Print version record. | ||
| 650 | 0 | |a Biophysics. | |
| 650 | 0 | |a Biomolecules. | |
| 650 | 0 | |a Physical biochemistry. | |
| 650 | 0 | |a Molecular structure. | |
| 650 | 0 | |a Proteins . | |
| 650 | 0 | |a Proteins. | |
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| 650 | 2 | 4 | |a Biological Structure Determination. |
| 650 | 2 | 4 | |a Protein Biochemistry. |
| 650 | 2 | 4 | |a Proteins. |
| 700 | 1 | |a Uversky, Vladimir N. |e editor. |0 (orcid)0000-0002-4037-5857 |1 https://orcid.org/0000-0002-4037-5857 |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
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