The Calabar Bean and its Alkaloids From Magic, via Miracle, to Memory /
Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoi...
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| Format: | Electronisk eBog |
| Sprog: | engelsk |
| Udgivet: |
Dordrecht :
Springer Netherlands : Imprint: Springer,
2023.
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| Udgivelse: | 1st ed. 2023. |
| Fag: | |
| Online adgang: | https://doi.org/10.1007/978-94-024-1191-1 |
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| Summary: | Investigations into Calabar beans (the dried ripe seeds of Physostigma venenosum) and their alkaloidal components compose a classical scientific journey throughout some one-and-a-half centuries and not only represent a fascinating aspect of the history of medicine but which is, moreover, still ongoing at the forefront of chemical and medical discovery. Those in particular involving its major such component, l-physostigmine, have led to an understanding of some of the fundamental mechanisms occurring in physiology, pharmacology and biochemistry and, either actually or potentially (by providing a template and thereby acting as a “lead compound”) have provided a useful treatment for a variety of neurological disorders associated with irregularities in cholinergic transmission in which augmentation of cholinergic activity has proved to be beneficial. |
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| Fysisk beskrivelse: | 1 online resource (XXVI, 267 p. 240 illus.). |
| ISBN: | 9789402411911 |
| DOI: | 10.1007/978-94-024-1191-1 |