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Discovery of Small-Molecule Modulators of Protein–RNA Interactions for Treating Cancer and COVID-19

This book describes the development of novel protein–RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein–RNA interactions to treat cancer and COVID-19. Modulating protein–RNA interactions with small molecules is expecte...

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Detalhes bibliográficos
Autor principal: Byun, Wan Gi (Autor)
Autor Corporativo: SpringerLink (Online service)
Formato: Recurso Eletrônico livro eletrônico
Idioma:inglês
Publicado em: Singapore : Springer Nature Singapore : Imprint: Springer, 2023.
Edição:1st ed. 2023.
coleção:Springer Theses, Recognizing Outstanding Ph.D. Research,
Assuntos:
Bioengineering.
Biotechnology.
Biophysics.
Protein folding.
RNA interference.
Biological and Physical Engineering.
Chemical Bioengineering.
Protein Folding.
RNA Interference.
Acesso em linha:https://doi.org/10.1007/978-981-19-7814-2
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Sumário:
  • 1. Introduction
  • 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28–Let-7 Interaction
  • 3. Discovery of Small-Molecule Modulators of Protein–RNA Interactions by Fluorescence Intensity-Based Binding Assay
  • 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2
  • Appendix.

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