Phase Separation in Living Cells Benefits and Risks /
This book presents the latest cutting-edge research on phase separation. It discusses the benefits and risks of phase separation for living cells from the perspectives of physics, chemistry, biology, and medicine. Phase separation is a physico-chemical process that induces a single solution of solve...
Gorde:
| Erakunde egilea: | |
|---|---|
| Beste egile batzuk: | |
| Formatua: | Baliabide elektronikoa eBook |
| Hizkuntza: | ingelesa |
| Argitaratua: |
Singapore :
Springer Nature Singapore : Imprint: Springer,
2023.
|
| Edizioa: | 1st ed. 2023. |
| Gaiak: | |
| Sarrera elektronikoa: | https://doi.org/10.1007/978-981-99-4886-4 |
| Etiketak: |
Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!
|
MARC
| LEADER | 00000nam a22000005i 4500 | ||
|---|---|---|---|
| 001 | 978-981-99-4886-4 | ||
| 003 | DE-He213 | ||
| 005 | 20260810161505.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 230929s2023 si | o |||| 0|eng d | ||
| 020 | |a 9789819948864 |9 978-981-99-4886-4 | ||
| 024 | 7 | |a 10.1007/978-981-99-4886-4 |2 doi | |
| 050 | 4 | |a QH506 | |
| 072 | 7 | |a PSD |2 bicssc | |
| 072 | 7 | |a SCI049000 |2 bisacsh | |
| 072 | 7 | |a PSD |2 thema | |
| 082 | 0 | 4 | |a 572 |2 23 |
| 245 | 1 | 0 | |a Phase Separation in Living Cells |h [electronic resource] : |b Benefits and Risks / |c edited by Riki Kurokawa. |
| 250 | |a 1st ed. 2023. | ||
| 264 | 1 | |a Singapore : |b Springer Nature Singapore : |b Imprint: Springer, |c 2023. | |
| 300 | |a 1 online resource (VIII, 318 p. 1 illus.). | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 341 | 0 | |b Table of contents navigation |2 onix | |
| 341 | 0 | |b Single logical reading order |2 onix | |
| 341 | 0 | |b Short alternative textual descriptions |2 onix | |
| 341 | 0 | |b Use of color is not sole means of conveying information |2 onix | |
| 341 | 0 | |b Use of high contrast between text and background color |2 onix | |
| 341 | 0 | |b Next / Previous structural navigation |2 onix | |
| 341 | 0 | |b All non-decorative content supports reading without sight |2 onix | |
| 347 | |a text file |b PDF |2 rda | ||
| 505 | 0 | |a Chapter 1. FUS aggregation by shear stress on pipetting and its suppression by non-coding RNA -- Chapter 2. Basics and recent advances in computational and theoretical methods for understanding the liquid-liquid phase separation -- Chapter 3.Promotion of liquid-liquid phase separation by G-quadruplex DNA and RNA -- Chapter 4. Phase regulation by chaperons -- Chapter 5. Regulation of aggregation of intrinsically disordered protein through phase separation: Risk management of phase separation -- Chapter 6. Molecular mechanisms of phase transition/separation of protein low-complexity sequences -- Chapter 7. Winding and Tangling. An Initial Phase of Membrane-less Organelle Formation (from a viewpoint of Cajal Bodies) -- Chapter 8. Formation and function of phase separated nuclear bodies directed by architectural noncoding RNA -- Chapter 9. Force-dependent remodeling of cell-to-cell adhesion through the regulation of phase separation -- Chapter 10. Neuronal RNA granules: Phase separation, dynamics, and higher brain functions -- Chapter 11. Liquid-liquid phase separation in structure and function of nuclear pore complex -- Chapter 12. Phase Separation Orchestrates Cancer Signaling: Biomolecular condensates as a promising target for cancer therapy -- Chapter 13. Regulatory interaction of intrinsically disordered regions of pathogenic proteins in neurodegenerative diseases -- Chapter 14. Functional properties of phase separation and intranuclear complex of FUS in the pathogenesis of ALS/FTLD -- Chapter 15. Functional responses of microglia to amyloid plaques -- Chapter 16. Emerging role of phage separation in COVID-19. | |
| 520 | |a This book presents the latest cutting-edge research on phase separation. It discusses the benefits and risks of phase separation for living cells from the perspectives of physics, chemistry, biology, and medicine. Phase separation is a physico-chemical process that induces a single solution of solvent and intrinsically disordered proteins (IDPs) to separate into two phases, one phase containing only solvent and the other containing IDPs in the solvent. A key molecule in phase separation is the intrinsically disordered region (IDR) proteins (IDPs), mostly comprised of RNA-binding proteins (RBPs). One of the major roles of phase separation is to generate condensates, membrane-less organelles including stress granule, Cajal body, and nucleolus. Biological actions of phase separation in various aspects of science have received increasing attention in recent years. The book consists of four parts; Part I on physics and chemistry includes topics on structural biology of RBP FUS/TLS and chaperone for phase separation, computational approach of phase separation, and chemistry of G-quadruplex of DNA and RNA. Part II on molecular biology presents molecular mechanism of IDR sequence phase separation and potential cellular function of these labile fibers, formation of membrane-less organelles, and roles of noncoding RNAs in phase separation. Part III on biology covers topics from nuclear pore complex, developmental biology regarding force-dependent remodeling, and neurobiology and higher order brain functions. Finally, Part IV on medicine presents condensates and cancer therapy, pathogenesis of neurodegenerative diseases based on IDPs, and responses of microglia to amyloid. The last chapter highlights the latest topic on how the SARS-Cov-2 virus takes advantage of phase separation for its infections. This book brings together the studies of phase separation in each area in a single volume. The comprehensive approach provides new insights to the research and will benefit the readers by responding to the emerging needs for understanding phase separation. | ||
| 532 | 8 | |a Accessibility summary: This PDF does not fully comply with PDF/UA standards, but does feature limited screen reader support, described non-text content (images, graphs), bookmarks for easy navigation and searchable, selectable text. Users of assistive technologies may experience difficulty navigating or interpreting content in this document. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com. | |
| 532 | 8 | |a No reading system accessibility options actively disabled | |
| 532 | 8 | |a Publisher contact for further accessibility information: accessibilitysupport@springernature.com | |
| 588 | |a Print version record. | ||
| 650 | 0 | |a Molecular biology. | |
| 650 | 0 | |a Biophysics. | |
| 650 | 0 | |a Medicine |x Research. | |
| 650 | 0 | |a Biology |x Research. | |
| 650 | 0 | |a Cytology. | |
| 650 | 0 | |a Biochemistry. | |
| 650 | 0 | |a Non-coding RNA. | |
| 650 | 1 | 4 | |a Molecular Biology. |
| 650 | 2 | 4 | |a Biophysics. |
| 650 | 2 | 4 | |a Biomedical Research. |
| 650 | 2 | 4 | |a Cell Biology. |
| 650 | 2 | 4 | |a Biochemistry. |
| 650 | 2 | 4 | |a Non-coding RNAs. |
| 700 | 1 | |a Kurokawa, Riki. |e editor. |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 710 | 2 | |a SpringerLink (Online service) | |
| 773 | 0 | |t Springer Nature eBook | |
| 776 | 0 | 8 | |i Printed edition: |z 9789819948857 |
| 776 | 0 | 8 | |i Printed edition: |z 9789819948871 |
| 776 | 0 | 8 | |i Printed edition: |z 9789819948888 |
| 856 | 4 | 0 | |u https://doi.org/10.1007/978-981-99-4886-4 |
| 912 | |a ZDB-2-SBL | ||
| 912 | |a ZDB-2-SXB | ||
| 950 | |a Biomedical and Life Sciences (SpringerNature-11642) | ||
| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||