Hematopoietic Stem Cells Keystone of Tissue Development and Regenerative Medicine /
This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, a...
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| Drugi avtorji: | , |
| Format: | Elektronski eKnjiga |
| Jezik: | angleščina |
| Izdano: |
Singapore :
Springer Nature Singapore : Imprint: Springer,
2023.
|
| Izdaja: | 1st ed. 2023. |
| Serija: | Advances in Experimental Medicine and Biology,
1442 |
| Teme: | |
| Online dostop: | https://doi.org/10.1007/978-981-99-7471-9 |
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| 245 | 1 | 0 | |a Hematopoietic Stem Cells |h [electronic resource] : |b Keystone of Tissue Development and Regenerative Medicine / |c edited by Meng Zhao, Pengxu Qian. |
| 250 | |a 1st ed. 2023. | ||
| 264 | 1 | |a Singapore : |b Springer Nature Singapore : |b Imprint: Springer, |c 2023. | |
| 300 | |a XV, 210 p. 1 illus. |b online resource. | ||
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| 490 | 1 | |a Advances in Experimental Medicine and Biology, |x 2214-8019 ; |v 1442 | |
| 505 | 0 | |a Chapter 1. Hematopoietic Stem Cell Development in Mammalian Embryos -- Chapter 2. Hematopoietic Stem Cells and Their Bone Marrow Niches -- Chapter 3. Emerging Roles of Epigenetic Regulators in Maintaining Hematopoietic Stem Cell Homeostasis -- Chapter 4. Metabolism in Hematopoiesis and Its Malignancy -- Chapter 5. The Origin of Clonal Hematopoiesis and Its Implication in Human Diseases -- Chapter 6. Ex vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells -- Chapter 7. N6-methyladenosine RNA Modification in Normal and Malignant Hematopoiesis -- Chapter 8. Immune System Influence on Hematopoietic Stem Cells and Leukemia Development -- Chapter 9. Learning from Zebrafish Hematopoiesis -- Chapter 10. Multi-lineage Differentiation from Hematopoietic Stem Cells -- Chapter 11. Gene Editing in Hematopoietic Stem Cells -- Chapter 12. Aging, Causes and Rejuvenation of Hematopoietic Stem Cells. | |
| 520 | |a This book renders a comprehensive understanding of hematopoietic stem cells (HSCs) from their embryonic development through adult maintenance to aging, in the studies conducted in zebrafish and mammals. Hematopoiesis provides a paradigm for understanding the development, maintenance, regeneration, aging and malignant transformation of mammalian organs. Sitting at the apex of the hematopoiesis hierarchy tree, HSCs orchestrate their proliferation, self-renewal, and differentiation to produce all the blood cell lineages throughout life, which represents the best example for somatic stem cell studies. In this book, key regulatory mechanisms for HSC self-renewal and differentiation are overviewed in an array of fields including epigenetics, metabolism and microenvironment regulation. It also highlights the HSC heterogeneity and clonal dynamics from the recent advanced single-cell technologies. This book elaborates on the research history of HSC studies and reveals how the insights from HSC studies shed light on their clinic application. It presents great value from the bench to the clinic. | ||
| 532 | 8 | |a Accessibility summary: This PDF does not fully comply with PDF/UA standards, but does feature limited screen reader support, described non-text content (images, graphs), bookmarks for easy navigation and searchable, selectable text. Users of assistive technologies may experience difficulty navigating or interpreting content in this document. We recognize the importance of accessibility, and we welcome queries about accessibility for any of our products. If you have a question or an access need, please get in touch with us at accessibilitysupport@springernature.com. | |
| 532 | 8 | |a No reading system accessibility options actively disabled | |
| 532 | 8 | |a Publisher contact for further accessibility information: accessibilitysupport@springernature.com | |
| 650 | 0 | |a Medicine |x Research. | |
| 650 | 0 | |a Biology |x Research. | |
| 650 | 0 | |a Stem cells. | |
| 650 | 0 | |a Developmental biology. | |
| 650 | 1 | 4 | |a Biomedical Research. |
| 650 | 2 | 4 | |a Stem Cell Biology. |
| 650 | 2 | 4 | |a Developmental Biology and Stem Cells. |
| 700 | 1 | |a Zhao, Meng. |e editor. |0 (orcid)0000-0001-7909-7594 |1 https://orcid.org/0000-0001-7909-7594 |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
| 700 | 1 | |a Qian, Pengxu. |e editor. |0 (orcid)0000-0001-5636-6704 |1 https://orcid.org/0000-0001-5636-6704 |4 edt |4 http://id.loc.gov/vocabulary/relators/edt | |
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| 776 | 0 | 8 | |i Printed edition: |z 9789819974702 |
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| 830 | 0 | |a Advances in Experimental Medicine and Biology, |x 2214-8019 ; |v 1442 | |
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| 950 | |a Biomedical and Life Sciences (R0) (SpringerNature-43708) | ||