Synthesis of 2,3-dihydroquinazoline -4(H)-one Derivatives by Intramolecular Oxidative Coupling Reaction as Cytotoxic Agent.
A series of 2,3-dihydroquinazoline-4(H)-ones derivatives having fused with 9,10- dihydrophenanthrene were prepared by a three component condensation reaction of isatoic anhydride, primary amines and aromatic aldehydes followed by the intramolecular oxidative coupling reaction in the presence of nont...
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| Format: | Online |
| Idioma: | anglès |
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Journal of Science
2026
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| Accés en línia: | http://journals.juniv.edu/index.php/jos/article/view/388 |
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| _version_ | 1873958350957314048 |
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| author | Farjana Akter Himo Md. Awlad Hossain Md. Farid Uddin Koushik Saha |
| author_facet | Farjana Akter Himo Md. Awlad Hossain Md. Farid Uddin Koushik Saha |
| author_sort | Farjana Akter Himo |
| collection | OJS |
| description | A series of 2,3-dihydroquinazoline-4(H)-ones derivatives having fused with 9,10- dihydrophenanthrene were prepared by a three component condensation reaction of isatoic anhydride, primary amines and aromatic aldehydes followed by the intramolecular oxidative coupling reaction in the presence of nontoxic FeCl3. This reaction involves dehydrogenative coupling of a various of 1,2-diarylethylene derivatives at temperature 0-5 oC. NMR and IR spectroscopy were used to characterize all the synthesized compounds and studied their cytotoxic property by Brine Shrimp Lethality Bioassay. Among these compounds, compound 2b and 3b showed moderate cytotoxicity with LC50 values 76.16 and 70.70 µg/ml respectively. |
| format | Online |
| id | ojs-388 |
| institution | My University |
| language | eng |
| publishDate | 2026 |
| publisher | Journal of Science |
| record_format | ojs |
| spelling | ojs-3882026-04-01T06:15:15Z Synthesis of 2,3-dihydroquinazoline -4(H)-one Derivatives by Intramolecular Oxidative Coupling Reaction as Cytotoxic Agent. Farjana Akter Himo Md. Awlad Hossain Md. Farid Uddin Koushik Saha 2,3-dihydroquinazoline-4(H)-one, Isatoic anhydride, There component condensation reaction, Intramolecular oxidative coupling, Cytotoxicity, Brine Shrimp Lethality Bioassay. A series of 2,3-dihydroquinazoline-4(H)-ones derivatives having fused with 9,10- dihydrophenanthrene were prepared by a three component condensation reaction of isatoic anhydride, primary amines and aromatic aldehydes followed by the intramolecular oxidative coupling reaction in the presence of nontoxic FeCl3. This reaction involves dehydrogenative coupling of a various of 1,2-diarylethylene derivatives at temperature 0-5 oC. NMR and IR spectroscopy were used to characterize all the synthesized compounds and studied their cytotoxic property by Brine Shrimp Lethality Bioassay. Among these compounds, compound 2b and 3b showed moderate cytotoxicity with LC50 values 76.16 and 70.70 µg/ml respectively. Journal of Science 2026-02-15 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Conference Proceedings Submission application/pdf http://journals.juniv.edu/index.php/jos/article/view/388 10.59185/jos.v45i2.388 Journal of Science; Vol. 45 No. 2 (2025): Jahangirnagar University Journal of Science 10.59185/jos.v45i2 eng http://journals.juniv.edu/index.php/jos/article/view/388/321 Copyright (c) 2026 Jahangirnagar University Journal of Science |
| spellingShingle | 2,3-dihydroquinazoline-4(H)-one, Isatoic anhydride, There component condensation reaction, Intramolecular oxidative coupling, Cytotoxicity, Brine Shrimp Lethality Bioassay. Farjana Akter Himo Md. Awlad Hossain Md. Farid Uddin Koushik Saha Synthesis of 2,3-dihydroquinazoline -4(H)-one Derivatives by Intramolecular Oxidative Coupling Reaction as Cytotoxic Agent. |
| title | Synthesis of 2,3-dihydroquinazoline -4(H)-one Derivatives by Intramolecular Oxidative Coupling Reaction as Cytotoxic Agent. |
| title_full | Synthesis of 2,3-dihydroquinazoline -4(H)-one Derivatives by Intramolecular Oxidative Coupling Reaction as Cytotoxic Agent. |
| title_fullStr | Synthesis of 2,3-dihydroquinazoline -4(H)-one Derivatives by Intramolecular Oxidative Coupling Reaction as Cytotoxic Agent. |
| title_full_unstemmed | Synthesis of 2,3-dihydroquinazoline -4(H)-one Derivatives by Intramolecular Oxidative Coupling Reaction as Cytotoxic Agent. |
| title_short | Synthesis of 2,3-dihydroquinazoline -4(H)-one Derivatives by Intramolecular Oxidative Coupling Reaction as Cytotoxic Agent. |
| title_sort | synthesis of 2 3 dihydroquinazoline 4 h one derivatives by intramolecular oxidative coupling reaction as cytotoxic agent |
| topic | 2,3-dihydroquinazoline-4(H)-one, Isatoic anhydride, There component condensation reaction, Intramolecular oxidative coupling, Cytotoxicity, Brine Shrimp Lethality Bioassay. |
| topic_facet | 2,3-dihydroquinazoline-4(H)-one, Isatoic anhydride, There component condensation reaction, Intramolecular oxidative coupling, Cytotoxicity, Brine Shrimp Lethality Bioassay. |
| url | http://journals.juniv.edu/index.php/jos/article/view/388 |
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