Translational glycobiology in human health and disease /
Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture.However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and...
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| Daljnji autori: | , |
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| Format: | e-knjiga |
| Jezik: | engleski |
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London, United Kingdom :
Academic Press,
2024.
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| Teme: | |
| Online pristup: | ScienceDirect |
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| 003 | OCoLC | ||
| 005 | 20260915095210.0 | ||
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| 007 | cr |n||||||||| | ||
| 008 | 231202s2024 enk o 000 0 eng d | ||
| 040 | |a YDX |b eng |c YDX |d OPELS |d OCLCL |d SFB |d OCLCF |d OCLCO | ||
| 020 | |a 9780128220023 |q (electronic bk.) | ||
| 020 | |a 0128220023 |q (electronic bk.) | ||
| 020 | |z 9780128196557 | ||
| 020 | |z 0128196556 | ||
| 035 | |a (OCoLC)1411278141 | ||
| 050 | 4 | |a QP701 | |
| 082 | 0 | 4 | |a 612.396 |2 23/eng/20240122 |1 https://id.oclc.org/worldcat/ddc/E36wGXKXcYTpwfXDY9CjvTRFBD |
| 245 | 0 | 0 | |a Translational glycobiology in human health and disease / |c edited by Michelle Kilcoyne, Lokesh Joshi. |
| 260 | |a London, United Kingdom : |b Academic Press, |c 2024. | ||
| 300 | |a 1 online resource | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Front Cover -- Translational Glycobiology in Human Health and Disease -- Translational Glycobiology in Human Health and Disease -- Copyright -- Contents -- List of contributors -- Introduction -- 1 -- Glycobiology -- 1 -- Carbohydrates and human glycosylation -- 1.1 Introduction -- 1.2 Glycoconjugate structures -- 1.2.1 Human N-linked glycosylation -- 1.2.2 Human O-linked glycosylation -- 1.2.3 Glycolipids -- 1.2.4 Proteoglycans -- 1.3 Nonhuman carbohydrates -- 1.4 Recycling of monosaccharides -- 1.5 Glycosylation and the exracellular matrix -- 1.6 Conclusion -- References -- 2 -- Lectins and their applications in biomedical research -- 2.1 Introduction -- 2.2 Plant lectins -- 2.2.1 Mannose binding -- 2.2.1.1 Con A -- 2.2.2 Galactose binding -- 2.2.2.1 PNA -- 2.2.3 N-Acetylgalactosamine binding -- 2.2.3.1 WFA -- 2.2.4 N-Acetylglucosamine binding -- 2.2.4.1 WGA -- 2.2.5 Fucose-binding -- 2.2.5.1 UEA-I -- 2.2.5.2 LTA -- 2.2.6 Sialic acid binding -- 2.2.6.1 SNA-I -- 2.3 Applications of lectins in biomedical research -- 2.3.1 Lectin agglutination assays -- 2.3.2 Lectin histochemistry -- 2.3.3 Lectin affinity chromatography -- 2.3.4 Enzyme-linked lectin assays -- 2.3.5 Lectin microarrays -- 2.4 Conclusions -- References -- 3 -- Carbohydrate-active enzymes -- 3.1 Introduction -- 3.2 Glycosyltransferases -- 3.2.1 Acceptor substrates -- 3.2.2 Donor substrates -- 3.2.3 Structural characteristics of glycosyltransferases -- 3.2.4 Mechanistic characterization of glycosyltransferases -- 3.2.4.1 Inverting glycosyltransferases -- 3.2.4.2 Retaining glycosyltransferases -- 3.2.5 Glycosyltransferases as tools in research, medicine, and bioindustry -- 3.3 Glycosidases -- 3.3.1 Glycosidase substrates -- 3.3.2 Structural characteristics of glycosidases -- 3.3.3 Mechanistic classification of glycosyl hydrolases -- 3.3.3.1 Inverting glycosidases. | |
| 505 | 8 | |a 3.3.3.2 Retaining glycosidases -- 3.3.4 Glycosidases as tools in research, medicine, and bioindustry -- Acknowledgments -- References -- 4 -- Carbohydrate sulfotransferases in glycosaminoglycan biosynthesis -- 4.1 Introduction -- 4.2 Two carbohydrate sulfotransferases superfamilies -- 4.3 Glycosaminoglycan sulfotransferases -- 4.3.1 Keratan sulfate sulfotransferases -- 4.3.2 Chondroitin sulfate sulfotransferases -- 4.3.3 Heparan sulfate sulfotransferases -- 4.4 Biomedical applications of sulfated glycosaminoglycans -- References -- 2 -- Glycobiology and health -- 5 -- The immune system from a glycobiological point of view -- 5.1 The immune system beyond pathogens: dissecting dangerous self and nonself signals -- 5.2 The sweet side of the immune system -- 5.3 Cellular immunity -- 5.3.1 The role of selectins and integrins in leukocyte migration and homing -- 5.3.1.1 Selectins and their ligands -- 5.3.2 Integrins -- 5.3.3 Macrophages in cellular innate immunity -- 5.3.4 C-type lectin-type receptors -- 5.3.5 Siglecs -- 5.3.6 Galectins -- 5.3.6.1 Galectin-1 and -3 -- 5.4 Adaptive immune response: B cells from a glycobiological perspective -- 5.4.1 B cell inhibitory coreceptors: CD22 and siglec-10 -- 5.4.2 Galectins regulating B cell development, activation, and differentiation -- 5.4.3 Immunoglobulins -- 5.5 Complement: the soluble component of innate immunity -- 5.5.1 Lectin pathway -- 5.6 Conclusions -- References -- 6 -- Host mucin glycosylation and gut symbiosis -- 6.1 Introduction -- 6.2 Mucin glycosylation along the GI tract -- 6.3 Role of mucin glycosylation in symbiosis: a bidirectional relationship -- 6.4 Mucin glycan utilization strategies by gut bacteria -- 6.5 Implication of mucin glycosylation in dysbiosis-mediated diseases -- 6.6 Future directions -- Acknowledgments -- References -- 7 -- Bifidobacteria-accessible carbohydrates in milk. | |
| 505 | 8 | |a 7.1 Introduction -- 7.2 General features of bifidobacteria HMO metabolism -- 7.2.1 Bifidobacterium longum subsp. infantis -- 7.2.2 Bifidobacterium bifidum -- 7.2.3 Bifidobacterium breve -- 7.2.4 Bifidobacterium longum subsp. longum -- 7.2.5 Bifidobacterium kashiwanohense -- 7.2.6 Bifidobacterium pseudocatenulatum -- 7.2.7 Other species and taxa -- 7.3 Milk glycoconjugate metabolism -- 7.4 Conclusions -- References -- 8 -- Extracellular vesicle glycosylation in transport, signaling, and function -- 8.1 A short introduction to extracellular vesicles -- 8.2 The beginning of the EV gold rush -- 8.3 The challenges of EV glycobiological analysis -- 8.4 Human EV glycome -- 8.5 Glycans in EV function -- 8.6 In closing, EV glycosylation and future prospects -- References -- 3 -- Glycobiology and disease -- 9 -- Protein glycosylation in cancer -- 9.1 Introduction -- 9.2 Hexosamine biosynthetic pathway and cancer -- 9.3 O-GlcNAcylation and cancer -- 9.4 N-glycosylation in cancer -- 9.5 O-linked N-acetylgalactosamine in cancer -- 9.5.1 Truncated O-linked glycans -- 9.5.2 Mucins -- 9.6 N- and O-linked glycan capping in cancer -- 9.7 Sialic acid in tumor biology -- 9.7.1 Neu5Gc-terminated glycans in tumor cell biology -- 9.7.2 Current approaches targeting sialylated glycans to improve antitumor response -- 9.8 Proteoglycans and glycosaminoglycans in cancer -- 9.9 Conclusions -- Acknowledgments -- References -- 10 -- Metabolic diseases: disorders of carbohydrate metabolism and lysosomal storage -- 10.1 Introduction -- 10.2 Disorders of carbohydrate metabolism -- 10.2.1 Disorders of galactose metabolism -- 10.2.1.1 Classic galactosemia (galactose-1-phosphate uridylyltransferase deficiency) and variants -- 10.2.1.2 Galactokinase deficiency -- 10.2.1.3 Galactose epimerase deficiency -- 10.2.1.4 Galactose mutarotase deficiency -- 10.2.2 Disorders of fructose metabolism. | |
| 505 | 8 | |a 11 -- The glycobiology of microbial infectious disease -- 11.1 Introduction -- 11.2 Carbohydrate-involved virulence factors -- 11.2.1 Microbial lectins -- 11.2.1.1 Helicobacter pylori lectins -- 11.2.1.2 Influenzavirus hemagglutinin -- 11.2.2 Bacterial toxins -- 11.2.2.1 Cholera toxin -- 11.2.2.2 Shiga toxin -- 11.2.3 Invasins -- 11.2.4 Lipopolysaccharides and lipooligosaccharides -- 11.2.4.1 Lipid A -- 11.2.4.2 Core oligosaccharide -- 11.2.4.3 Campylobacter jejuni LOS and molecular mimicry -- 11.2.4.4 O-specific polysaccharide of LPS -- 11.2.4.5 H. pylori LPS and persistent colonization -- 11.2.5 Capsular polysaccharides -- 11.2.6 Biofilms -- 11.2.6.1 Biofilms and exopolysaccharides -- 11.2.6.1.1 Poly-N-acetylglucosamine -- 11.2.6.1.2 Pseudomonas aeruginosa biofilm EPSs -- 11.2.6.2 Biofilms and lectins -- 11.2.6.2.1 Pseudomonas aeruginosa lectins -- 11.3 Current carbohydrate-based antimicrobial therapeutics and prophylactics -- 11.3.1 Bacterial polysaccharide vaccines -- 11.3.1.1 Neisseria meningitidis CPS vaccines -- 11.3.2 Antibiotics -- 11.3.3 Carbohydrate-based therapeutics -- 11.3.3.1 Neuraminidase inhibitors for influenza treatment -- 11.4 Current research and development for carbohydrate-based antimicrobial strategies -- 11.4.1 Polysaccharide vaccines -- 11.4.1.1 PNAG as a "universal" vaccine candidate -- 11.4.2 Anti-adhesion therapeutics -- 11.4.2.1 Uropathogenic Escherichia coli FimH and PapG -- 11.5 Conclusions -- Acknowledgments -- References -- 4 -- Glycotechnologies -- 12 -- Elucidation of the structure of carbohydrates and their interactions by nuclear magnetic resonance spectroscopy -- 12.1 Introduction -- 12.2 Assignment of carbohydrate resonances -- 12.3 Study of carbohydrate conformations -- 12.4 NMR tools for analyzing the interplay between carbohydrates and proteins -- References. | |
| 505 | 8 | |a 13 -- Development of glycosensors and their applications. | |
| 520 | |a Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture.However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. | ||
| 650 | 0 | |a Carbohydrates in human nutrition. | |
| 650 | 0 | |a Glycomics |x Health aspects. | |
| 650 | 0 | |a Glycomics |x Therapeutic use. | |
| 650 | 6 | |a Glucides dans l'alimentation humaine. |0 (CaQQLa)201-0320057 | |
| 650 | 6 | |a Glycomique |0 (CaQQLa)201-0451911 |x Emploi en thérapeutique. |0 (CaQQLa)201-0373975 | |
| 650 | 7 | |a Carbohydrates in human nutrition |2 fast |0 (OCoLC)fst00846768 | |
| 700 | 1 | |a Kilcoyne, Michelle. | |
| 700 | 1 | |a Joshi, Lokesh. | |
| 776 | 0 | 8 | |c Original |z 0128196556 |z 9780128196557 |w (OCoLC)1138674807 |
| 776 | 0 | 8 | |i Print version: |t Translational glycobiology in human health and disease. |d Amsterdam : Academic Press, 2023 |z 9780128196557 |w (OCoLC)1402273605 |
| 856 | 4 | 0 | |3 ScienceDirect |u https://www.sciencedirect.com/science/book/9780128196557 |