Insulin : deficiency, excess and resistance in human disease /
Insulin: Deficiency, Excess and Resistance in Human Disease provides an overview of the role of insulin in the pathogenesis of prevalent non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, and cancer, along with a comprehensive review of insulin replacement therapies...
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| Muut tekijät: | |
|---|---|
| Aineistotyyppi: | E-kirja |
| Kieli: | englanti |
| Julkaistu: |
[S.l.] :
Academic Press,
2023.
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| Aiheet: | |
| Linkit: | ScienceDirect |
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| 082 | 0 | 4 | |a 615.3/65 |2 23/eng/20240205 |1 https://id.oclc.org/worldcat/ddc/E3VJKpMTFGKGxfJRcydRJxXcgh |
| 245 | 0 | 0 | |a Insulin : |b deficiency, excess and resistance in human disease / |c edited by Andrew J. Krentz. |
| 260 | |a [S.l.] : |b Academic Press, |c 2023. | ||
| 300 | |a 1 online resource | ||
| 588 | 0 | |a Print version record. | |
| 505 | 0 | |a Front Cover -- Insulin -- Copyright Page -- Contents -- List of contributors -- Foreword -- Preface -- 1 Normal physiology: insulin secretion and insulin action -- 1 Insulin biosynthesis and release in health and disease -- Insulin biosynthesis -- The insulin gene-comparative physiology -- Transcriptional regulation of insulin gene expression -- Metabolic regulation of insulin gene expression -- Regulation of preproinsulin transcript stability -- Regulation of translation of the preproinsulin transcript -- Regulation of the processing of the preproinsulin peptide -- Insulin release -- Concluding remarks -- References -- 2 Classic metabolic actions of insulin in humans: from physiology to disease and novel pharmacotherapeutics -- Introduction -- Insulin structure and synthesis -- Physiological actions of action -- Insulin transport and the insulin receptor -- Cellular insulin signaling -- Metabolic actions of insulin in classic target tissues -- Carbohydrate metabolism -- Lipid metabolism -- Protein metabolism -- Insulin dose-response considerations -- Carbohydrate metabolism -- Regulation of the postabsorptive metabolic state -- Response to oral glucose ingestion or mixed meals -- Lipid metabolism -- Fasting state -- Postprandial state -- Nonclassic roles of adipocytes: implications for insulin action and cardiometabolic disease -- Brown adipose tissue -- Amino acid and protein metabolism -- Clinical states of acute metabolic decompensation associated with insulin deficiency -- Diabetic ketoacidosis -- Hyperglycemic hyperosmolar state -- References -- 3 Nonclassic effects of insulin: physiological actions on the vascular tissues and pathophysiological contributions to athe... -- Introduction -- Overview of insulin and cardiovascular disease -- Effects of insulin on the vascular tissues and atherogenesis. | |
| 505 | 8 | |a Congenital disorders of glycosylation -- Diagnosis -- Diagnostic evaluation -- Genetic testing -- Management -- Medical therapy -- 18F-DOPA PET -- Surgery -- Diazoxide unresponsive diffuse hyperinsulinism -- Outcomes -- Glycemic outcomes -- Neurologic outcomes -- Conclusion -- References -- 9 Hypoglycemic disorders in adults -- Clinical manifestations -- Causes of hypoglycemia -- Hypoglycemia in the setting of diabetes therapy -- Diagnostic evaluation -- Who to evaluate? -- Diagnostic approach -- The supervised fast -- Interpretation of data -- Postprandial evaluation -- Localization studies -- Management -- Insulinoma -- Medical management -- Diazoxide -- Somatostatin analogs -- Other medications -- Other therapies -- Postgastric bypass hypoglycemia -- NIPHS -- Recurrence, survival, and surveillance -- Conclusion -- References -- 2c Insulin resistance in human disease -- 10 Obesity and insulin resistance: pathophysiology guiding precision therapy -- Introduction -- Insulin resistance: substrates and genetics -- Effect of adiposity on hepatic and extrahepatic insulin action -- Insulin suppression of lipolysis -- Insulin suppression of glycogenolysis and gluconeogenesis -- Effects of nonglucose nutrients on insulin secretion and action in people with prediabetes -- Insulin secretion, action, glucose effectiveness and postprandial glucose metabolism in type 2 diabetes -- Splanchnic glucose uptake and splanchnic glucose production -- Nocturnal regulation of glucose homeostasis in type 2 diabetes -- Effects of cortisol and glucagon on nocturnal glucose production in type 2 diabetes -- Therapeutic approaches -- Summary and conclusions -- References -- 11 The cardiometabolic syndrome and vascular disease: pivotal role of insulin -- Introduction -- Pathophysiology of atherosclerosis -- Role of insulin resistance in atherosclerosis. | |
| 505 | 8 | |a Role of insulin resistance and hyperglycemia in microvascular disease -- Genetic and epigenetic associations with insulin resistance and cardiovascular disease -- Clinical features of cardiometabolic syndrome and insulin resistance -- Prevention of diabetes and ASCVD -- Medical therapies for primary prevention and treatment of metabolic syndrome components: a brief overview -- Treatment of type 2 diabetes mellitus -- Conclusions -- References -- 12 Insulin resistance, hyperinsulinemia, and cancer: pathogenic considerations and therapeutic opportunities -- Introduction -- Visceral adipose tissue, inflammation, and insulin resistance -- Insulin resistance, hyperinsulinemia and cancer: epidemiologic links -- Visceral obesity, metabolic syndrome, and cancer -- Insulin resistance, hyperinsulinemia, and cancer -- Insulin resistance, hyperinsulinemia, and cancer: mechanisms -- Systemic inflammation -- The insulin IGF-1 axis -- Insulin and IGF-1 -- Insulin, IGF-1, and the tumor microenvironment -- Sex steroids -- Insulin and the gut microbiome -- Therapeutic considerations -- Exogenous insulin -- Insulin and cancer prevention -- Diet, exercise, and intentional weight loss -- Pharmacologic therapies -- Hyperinsulinemia and cancer cachexia -- Summary -- Funding -- Conflict of interest -- References -- 13 Insulin and neurodegenerative diseases -- Introduction -- The brain is an insulin-sensitive organ -- Receptor expression in the brain -- Insulin production and transport across the blood-brain barrier -- Insulin and insulin-like signaling in the brain -- Control of cellular metabolism by insulin -- Abnormalities associated with dysregulated insulin/IGF-1 signaling -- AD brains show insulin and IGF1 resistance -- Sources of brain insulin resistance in neurodegeneration -- Diabetes interventions for the prevention or treatment of neurodegeneration -- Conclusions. | |
| 520 | |a Insulin: Deficiency, Excess and Resistance in Human Disease provides an overview of the role of insulin in the pathogenesis of prevalent non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, and cancer, along with a comprehensive review of insulin replacement therapies and novel cardioprotective and. | ||
| 650 | 0 | |a Insulin |x Therapeutic use |x Effectiveness. | |
| 650 | 0 | |a Insulin resistance. | |
| 650 | 2 | |a Insulin Resistance |0 (DNLM)D007333 | |
| 650 | 6 | |a Insulinorésistance. |0 (CaQQLa)201-0103063 | |
| 650 | 7 | |a Insulin resistance |2 fast |0 (OCoLC)fst00974526 | |
| 650 | 7 | |a Insulin |x Therapeutic use |x Effectiveness |2 fast |0 (OCoLC)fst00974520 | |
| 700 | 1 | |a Krentz, Andrew J. | |
| 776 | 0 | 8 | |i Print version: |z 0323917070 |z 9780323917070 |w (OCoLC)1284289935 |
| 776 | 0 | 8 | |i Print version: |t Insulin. |d Amsterdam : Academic Press, 2023 |z 9780323917070 |w (OCoLC)1377217312 |
| 856 | 4 | 0 | |3 ScienceDirect |u https://www.sciencedirect.com/science/book/9780323917070 |