Scale-up and chemical process for microbial production of plant-derived bioactive compounds : from laboratory to industry.
This book provides a comprehensive overview of the processes involved in the microbial production of plant-derived bioactive compounds, from laboratory research to commercial production. It covers various aspects of scale-up and chemical processes, including optimization of fermentation, metabolic e...
Guardado en:
| Formato: | eBook |
|---|---|
| Lenguaje: | inglés |
| Publicado: |
[S.l.] :
Academic Press,
2024.
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| Colección: | Developments in microbial cell factories
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| Materias: | |
| Acceso en línea: | ScienceDirect |
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| 001 | on1427658734 | ||
| 003 | OCoLC | ||
| 005 | 20260915095211.0 | ||
| 006 | m o d | ||
| 007 | cr |n||||||||| | ||
| 008 | 240324s2024 xx o 000 0 eng d | ||
| 040 | |a YDX |b eng |c YDX |d OPELS |d OCLCO |d N$T |d OCLCQ |d OCLCL |d UKAHL |d SFB |d OCLCF |d OCLCO | ||
| 020 | |a 9780443155857 |q (electronic bk.) | ||
| 020 | |a 0443155852 |q (electronic bk.) | ||
| 020 | |z 9780443155840 | ||
| 020 | |z 0443155844 | ||
| 035 | |a (OCoLC)1427658734 | ||
| 050 | 4 | |a QP517.B44 | |
| 082 | 0 | 4 | |a 660.6 |2 23/eng/20240408 |1 https://id.oclc.org/worldcat/ddc/E3D9VwxgGwwXmRPH4fbcFbw7TX |
| 245 | 0 | 0 | |a Scale-up and chemical process for microbial production of plant-derived bioactive compounds : |b from laboratory to industry. |
| 260 | |a [S.l.] : |b Academic Press, |c 2024. | ||
| 300 | |a 1 online resource | ||
| 490 | 0 | |a Developments in microbial cell factories | |
| 505 | 0 | |a Front Cover -- Scale-up and Chemical Process for Microbial Production of Plant-Derived Bioactive Compounds -- Copyright Page -- Contents -- List of contributors -- 1 Advances and prospects for advanced biomanufacturing -- Introduction -- Optimization and scale-up of fermentation process based on process parameter correlation analysis -- Key technologies and applications of optimization and scale-up of biological fermentation process based on process model -- Rational scale-up methodology combining cellular physiology and flow field of biochemical reactor -- Intelligent biomanufacturing is a strong driving force for the transformation and upgrading of bioeconomy -- Intelligent sensing of cell metabolism based on advanced online sensing technology -- Intelligent analysis of biological processes based on data science -- Intelligent manufacturing of industrial-scale bioprocess -- Acknowledgment -- References -- 2 Different microbial strategies used for industrial-scale production of plant-derived bioactive compounds -- Metabolic engineering facilitates de novo synthesis -- Typical steps -- Gene identification and characterization -- Suitable microbial host -- Introduction of target gene -- Optimization of target gene expression level -- Metabolic network modification -- Positive strains selection -- Scale-up fermentation -- Enzyme engineering for continuous biotransformation -- Enzyme engineering -- Identification of target enzyme with desired properties -- Mutant library generation -- High-throughput screening -- Processing technology -- Whole-cell catalysis -- Cell-free catalysis -- References -- 3 Optimization parameters for efficient scale-up of fermentation process -- Introduction -- Fermentation process characterization -- Process data acquiring, fusing, and visualization -- Laboratory scale-down tools for efficient and rational scale-up. | |
| 505 | 8 | |a Emerging trends and future directions -- References -- 4 Development of economic extraction and purification process for plant-derived bioactive compounds -- Introduction -- Separation and purification methods for bioactive compounds -- Solvent extraction method -- Microwave extraction method -- Adsorption separation technology -- Activated carbon adsorption separation technology -- Macroporous resin adsorption separation technology -- Foam separation technique -- Membrane separation technology -- Simulated moving bed chromatography -- Supercritical fluid extraction technology -- Existing problems and prospects -- Acknowledgment -- Declaration of interest -- References -- 5 Screening and characterization of probiotics for large-scale production of plant-derived prebiotics -- Methods for screening probiotics for plant fermentation -- Isolation of probiotics from plant-based foods and in vitro studies -- Whole-genome sequencing technologies -- Animal models -- Human clinical studies -- Generation of prebiotics from engineered microbes via plant biomass fermentation -- Grain fermentation to produce prebiotics -- Bean fermentation for prebiotic production -- Fruit and vegetable fermentation for prebiotic production -- Fermentation of other plants for prebiotic production -- Fermented tea -- Fermented feed -- Isolation of bioactive compounds -- Extraction of dietary fiber, polysaccharide, and oligosaccharide -- Physical methods -- Water extraction -- Microwave-assisted extraction -- Ultrasonic extraction -- Ultra-high-pressure extraction -- Chemical separation -- Enzyme separation -- Membrane separation -- Separation and extraction of functional peptides -- Macroporous resin adsorption chromatography -- Gel filtration chromatography -- Ion exchange chromatography -- Affinity chromatography -- Reversed-phase high-performance liquid chromatography (RP-HPLC). | |
| 505 | 8 | |a Separation and extraction of phenols -- Commercial production of plant-derived bioactive compounds -- Cereal-based production -- Vegetable- and fruit-based production -- Soy-based production -- Other plant-based materials -- Perspective -- Acknowledgments -- Declaration of interest -- References -- 6 Designing and engineering synthetic microbiota to utilize plant lignin-based biomass for the synthesis of bioactive compounds -- Introduction -- Upstream processing of lignin -- Lignin fractionation -- Depolymerization of lignin -- Acid/base-catalyzed depolymerization -- Oxidative depolymerization -- Reductive depolymerization -- Thermochemical transformation -- Photocatalytic depolymerization -- Bioprocessing -- Downstream bioprocessing of lignin -- Efficient utilization of lignin hydrolysate by lignin-degrading bacteria -- Transformation of platform compounds by lignin-degrading bacteria -- Biosynthesis of value-added aromatic compounds from platform compounds -- Biosynthesis of amines from platform compounds -- Biosynthesis of other refined compounds from platform compounds -- Conclusion and outlook -- Acknowledgments -- Author contributions -- Competing financial interests -- References -- 7 The principles to design and optimization of industrial bioprocesses -- Introduction -- Typical modes of bioprocess used in production -- Batch fermentation -- Continuous fermentation -- Fed-batch fermentation -- Design principles of the fermentation process -- Each fermentation type has its optimal application scenarios -- Basic principles for bioprocess design -- Strategies to improve performance of bioprocess -- Optimization of fermentation process based on online/offline parameters -- Optimization of fermentation processes based on predictions from machine learning -- Flow field optimization within bioreactors -- Changing the stirring method. | |
| 505 | 8 | |a Improving the flow field with baffles -- Simulation and optimization of the flow fluid within the fermenter -- Perspectives -- Acknowledgments -- Declaration of interests -- References -- 8 The synthetic probiotic microbiota and their potential applications in the production of plant-derived products -- Introduction -- Probiotics derived from fermented foods -- Synthetic probiotic microbiota -- Production of plant-derived products using synthetic probiotic microbiota -- Conclusions and perspectives -- Acknowledgments -- Declaration of interests -- References -- 9 Fermentation utilizing engineered microbes: revolutionizing the production of commercial products from plant-derived bioa... -- Abbreviations -- Introduction -- Commonly used engineered microorganisms for plant bioactive compound synthesis -- Escherichia coli -- Saccharomyces cerevisiae -- Advances in engineering metabolic pathways for plant bioactive compound synthesis -- Terpenoids -- Monoterpenoids -- Geraniol -- Linalool -- Sesquiterpenes -- Artemisinin -- Nerolidol -- Diterpenoids -- Triterpenoids -- Tetraterpenoids -- Alkaloids -- Monoterpene indole alkaloids -- Benzylisoquinoline alkaloids -- Flavonoids -- Flavanones -- Isoflavones -- Factors impacting the fermentation process of plant-derived bioactive compounds -- Strain engineering and optimization -- Carbon source -- Nitrogen source -- Incubation temperature -- Three main modes: batch, fed-batch, and continuous fermentation -- Batch mode -- Fed-batch mode -- Continuous mode -- Scaling up of industrial microbial fermentations -- Fermentation techniques: solid-state fermentation and submerged fermentation -- Solid-state fermentation -- Submerged fermentation -- Challenges ahead for the microbial synthesis of plant bioactive compounds -- Summary and future prospects -- References. | |
| 520 | |a This book provides a comprehensive overview of the processes involved in the microbial production of plant-derived bioactive compounds, from laboratory research to commercial production. It covers various aspects of scale-up and chemical processes, including optimization of fermentation, metabolic engineering, and enzyme engineering. The book is intended for researchers and practitioners in the fields of biotechnology, chemical engineering, and synthetic biology, offering insights into the design and optimization of microbial cell factories. It also discusses the economic extraction and purification of bioactive compounds, as well as the application of synthetic probiotic microbiota. The book aims to bridge the gap between laboratory-scale research and industrial-scale applications. |7 Generated by AI | ||
| 650 | 0 | |a Bioactive compounds. | |
| 650 | 0 | |a Industrial microbiology. | |
| 650 | 6 | |a Composés bioactifs. |0 (CaQQLa)201-0046484 | |
| 650 | 6 | |a Microbiologie industrielle. |0 (CaQQLa)201-0014954 | |
| 650 | 7 | |a Bioactive compounds |2 fast |0 (OCoLC)fst00831933 | |
| 650 | 7 | |a Industrial microbiology |2 fast |0 (OCoLC)fst00971352 | |
| 776 | 0 | 8 | |i Print version: |z 0443155844 |z 9780443155840 |w (OCoLC)1395178311 |
| 856 | 4 | 0 | |3 ScienceDirect |u https://www.sciencedirect.com/science/book/9780443155840 |