Εξώφυλλο

Exosomal RNA : role in human diseases and therapy /

This scholarly volume explores the role of exosomal RNA in human diseases and therapeutic applications. Edited by experts in microbiology, biosciences, and research, the book delves into the biogenesis, isolation, and functions of exosomal RNA, highlighting its significance in various pathological c...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:Αγγλικά
Έκδοση: London : Academic Press, [2024].
Θέματα:
RNA.
Exosome Multienzyme Ribonuclease Complex
Neoplasms
RNA
ARN.
Διαθέσιμο Online:ScienceDirect
Ετικέτες: Προσθήκη ετικέτας
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Πίνακας περιεχομένων:
  • Front Cover
  • Exosomal RNA
  • Exosomal RNA: ROLE IN HUMAN DISEASES AND THERAPY
  • Contents
  • Contributors
  • Preface
  • One
  • Exosomal RNA-an introduction
  • 1 Introduction
  • 2 Characteristics of exosomal RNA
  • 2.1 Exosomal MiRNAs
  • 2.2 Exosomal circular RNAs
  • 3 Importance of exosomal RNAs
  • 4 Role of exosomal RNAs in different diseases
  • 4.1 Cancer diagnosis and prognosis
  • 4.2 Autophagy-related disorder
  • 4.3 Diabetic and metabolic diseases
  • 4.4 Immunological diseases
  • 4.5 Neurodegenerative diseases
  • 4.6 Aging-related disorder
  • 4.7 Cardiovascular diseases
  • 4.8 Renal disease [81]
  • 4.9 Bacterial infection diseases
  • 4.10 Wound healing and tissue repairing
  • 5 Concluding remarks
  • References
  • Two
  • Biogenesis of exosome and exosomal RNA and its isolation and physical characterizations
  • 1 Introduction
  • 1.1 Biogenesis and release of exosomes
  • 1.2 Endosomal sorting complex required for transport and exosomal biogenesis
  • 1.3 ESCRT-independent mechanism of exosome biogenesis
  • 1.4 MVBs transport to the membrane and release exosomes
  • 1.5 Basal composition and cargo
  • 1.5.1 Nucleic acids
  • 1.5.2 Proteins
  • 1.5.3 Lipids
  • 2 Exosome isolation
  • 2.1 Ultrafiltration
  • 2.2 Ultracentrifugation
  • 2.2.1 Differential ultracentrifugation
  • 2.2.2 Density gradient ultracentrifugation
  • 2.3 Precipitation
  • 2.4 Immunoaffinity capture
  • 2.5 Size-exclusion chromatography
  • 3 Characterization of exosomes
  • 3.1 Ultrastructural analysis
  • 3.2 Nanoparticle tracking analysis
  • 3.2.1 Advantages of NTA
  • 3.2.2 Disadvantages of NTA
  • 3.3 Atomic force microscopy
  • 3.4 Flow cytometry
  • 3.5 Western blotting
  • 3.6 Other methods
  • 3.6.1 Fluid flow fraction
  • 3.6.2 Raman spectroscopy
  • 4 Conclusion
  • References
  • Three
  • Exosomal RNA in cancer progression
  • 1 Introduction
  • 2 Exosomal RNAs in cancer progression
  • 2.1 Gastrointestinal cancer progression
  • 2.1.1 Gastric cancer progression
  • 2.1.2 Pancreatic cancer progression
  • 2.1.3 Hepatocellular carcinoma progression
  • 2.1.4 Colorectal cancer progression
  • 2.2 Blood cancer progression
  • 2.3 Lung cancer progression
  • 2.4 Breast cancer progression
  • 2.5 Glioma progression
  • 2.6 Thyroid cancer progression
  • 2.7 Cervical cancer progression
  • 2.8 Prostate cancer progression
  • 2.9 Ovarian cancer progression
  • 3 Conclusion
  • References
  • Further reading
  • Four
  • Exosomal RNA as a biomarker in cancer diagnostics and therapy
  • 1 Introduction
  • 2 Exosomal RNA as a biomarker for diagnosis and therapy outcome of common tumor types
  • 2.1 Brain cancer
  • 2.2 Oral cancer
  • 2.3 Breast cancer
  • 2.4 Lung cancer
  • 2.5 Skin cancer
  • 2.6 Liver cancer
  • 2.7 Gastric cancer
  • 2.8 Pancreatic cancer
  • 2.9 Prostate cancer
  • 2.10 Gynecological cancers
  • 2.11 Colorectal cancer
  • 2.12 Hematological cancers
  • 3 Conclusion
  • References
  • Five
  • Exosomal RNA and autophagy
  • 1 Introduction
  • 2 Exosome biogenesis and composition

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