Translational orthopedics /
Enregistré dans:
| Autres auteurs: | , , , , |
|---|---|
| Format: | Électronique eBook |
| Langue: | anglais |
| Publié: |
London, United Kingdom ; San Diego, CA :
Academic Press, an imprint of Elsevier,
[2024]
|
| Collection: | Handbook for designing and conducting translational research
|
| Sujets: | |
| Accès en ligne: | ScienceDirect |
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| 001 | on1430724576 | ||
| 003 | OCoLC | ||
| 005 | 20260915095213.0 | ||
| 006 | m o d | ||
| 007 | cr |n||||||||| | ||
| 008 | 240422s2024 enka ob 001 0 eng d | ||
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| 019 | |a 1432131891 | ||
| 020 | |a 0323885624 |q electronic book | ||
| 020 | |a 9780323885621 |q (electronic bk.) | ||
| 020 | |z 9780323856638 |q paperback | ||
| 020 | |z 0323856632 |q paperback | ||
| 035 | |a (OCoLC)1430724576 |z (OCoLC)1432131891 | ||
| 050 | 4 | |a RD731 |b .T73 2024 | |
| 060 | 4 | |a WE 20 | |
| 082 | 0 | 4 | |a 616.7 |2 23/eng/20240503 |1 https://id.oclc.org/worldcat/ddc/E448D7GdKByr3hDWbfhcJCXBp6 |
| 245 | 0 | 0 | |a Translational orthopedics / |c edited by Adam E.M. Eltorai, Jeffrey A. Bakal, Jack M. Haglin, Jospeh A. Abboud, Joseph J. Crisco. |
| 264 | 1 | |a London, United Kingdom ; |a San Diego, CA : |b Academic Press, an imprint of Elsevier, |c [2024] | |
| 300 | |a 1 online resource (xv, 561 pages) : |b illustrations (chiefly color). | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 340 | |p illustration |0 http://rdaregistry.info/termList/IllusContent/1014 |2 rdaill | ||
| 340 | |g polychrome |0 http://rdaregistry.info/termList/RDAColourContent/1003 |2 rdacc | ||
| 490 | 0 | |a Handbook for designing and conducting translational research | |
| 504 | |a Includes bibliographical references and index. | ||
| 588 | |a Description based on online resource; title from digital title page (viewed on May 03, 2024). | ||
| 505 | 0 | |a Front Cover -- Translational Orthopedics -- Handbook for Designing and Conducting Clinical and Translational Research -- Translational Orthopedics -- Copyright -- Contents -- List of contributors -- Preface -- I -- Introduction -- 1 -- Introduction -- Definitions and objectives -- Structure -- How to use this book -- Intervention development -- Clinical emphasis -- Limitations -- References -- 2 -- Translational process -- Key points -- Introduction section/why it matters -- Translational research definition -- Historical perspective -- The process of translational research | |
| 505 | 8 | |a T0: Basic and applied research -- T1: Translation to humans -- T2: Translation to patients -- T3: Translation to practice -- T4: Translation to community -- Conclusion -- Get started -- Potential pitfalls -- Examples -- References -- 3 -- Scientific method -- Key points -- Introductory section/Why it matters -- Text -- Observation -- Question -- Hypothesis -- Experiment -- Analysis -- Conclusion -- Get started -- Potential pitfalls -- Examples of scientific method -- Resources -- References -- 4 -- Basic research -- Key points -- Why it matters -- Basic research and the "reductionist approach" | |
| 505 | 8 | |a Disciplines of basic research -- Get started -- References -- II -- Pre-clinical -- 5 -- Overview of preclinical research -- Key points -- Introduction section/why it matters -- Get started -- Potential pitfalls -- Examples -- Resources -- References -- 6 -- Formulating a researchable question: a critical step for facilitating good clinical research -- Key points -- Introduction -- Population -- Intervention -- Comparison -- Outcome -- Time frame -- Feasibility -- Interesting -- Novel -- Ethical -- Relevant -- Getting started -- Pitfalls to avoid -- Additional resources -- References | |
| 505 | 8 | |a 7 -- Types of interventions: drug, device, diagnostic, procedural technique, or behavior change -- Key points -- Introduction -- Getting started -- Potential pitfalls -- Resources -- References -- 8 -- Drug discovery -- Key points -- Why it matters? -- Drug discovery -- Small molecules -- Biological therapies -- Prodrugs -- The drug discovery process -- Target discovery -- Molecular diagnostics -- Antibodies -- Genetics -- Lead identification and lead optimization -- Disciplines and common lab methods and techniques -- Gel electrophoresis -- High-throughput screening | |
| 505 | 8 | |a Enzyme-linked immunosorbent assay -- Polymerase chain reaction -- Western blot -- Major areas of current investigation -- Osteoarthritis -- Chronic pain -- Three real-world examples of drug discovery -- Amyotrophic lateral sclerosis -- Osteoporosis -- Knee arthritis -- How to obtain funding and resources -- Get started with drug discovery -- Common mistakes and tips for drug discovery -- References -- 9 -- Drug testing -- Key points -- "Why it matters?" -- Drug testing -- In vitro -- In vivo -- Harm -- Toxicity and dosing -- Good laboratory practice -- Get started -- Potential pitfalls | |
| 650 | 0 | |a Orthopedics |x Research. | |
| 650 | 2 | |a Orthopedics |0 (DNLM)D009985 | |
| 650 | 2 | |a Translational Research, Biomedical |0 (DNLM)D057170 | |
| 650 | 6 | |a Orthopédie |0 (CaQQLa)201-0033762 |x Recherche. |0 (CaQQLa)201-0379425 | |
| 650 | 6 | |a Recherche translationnelle. |0 (CaQQLa)000278086 | |
| 650 | 7 | |a Orthopedics |x Research |2 fast |0 (OCoLC)fst01048571 | |
| 655 | 0 | |a Electronic books. | |
| 700 | 1 | |a Eltorai, Adam E. M., |e editor. |1 https://id.oclc.org/worldcat/entity/E39PCjFMMWYGvmVbhmFhkpHXBP | |
| 700 | 1 | |a Bakal, Jeffrey A., |d 1975- |e editor. | |
| 700 | 1 | |a Haglin, Jack M., |e editor. | |
| 700 | 1 | |a Abboud, Joseph A., |e editor. |1 https://id.oclc.org/worldcat/entity/E39PCjqt8w4FWtrPjFhF3DKFfC | |
| 700 | 1 | |a Crisco, Joseph J., |e editor. |1 https://id.oclc.org/worldcat/entity/E39PBJtH6XFwGxY9HcMdd4q4v3 | |
| 776 | 0 | 8 | |i Print version: |z 0323856632 |z 9780323856638 |w (OCoLC)1394115682 |
| 856 | 4 | 0 | |3 ScienceDirect |u https://www.sciencedirect.com/science/book/9780323856638 |