Application of gellan gum as a biomedical polymer /
This book provides a comprehensive examination of the applications of gellan gum as a biomedical polymer. It explores the sources, properties, and chemistry of gellan gum, focusing on its diverse applications in drug delivery, wound dressing, cartilage and scaffold applications, dentistry, and more....
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| Other Authors: | , |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
London :
Academic Press,
2024.
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| Subjects: | |
| Online Access: | ScienceDirect |
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| 001 | on1435616390 | ||
| 003 | OCoLC | ||
| 005 | 20260915095210.0 | ||
| 006 | m o d | ||
| 007 | cr |n||||||||| | ||
| 008 | 240601s2024 enk o 000 0 eng d | ||
| 040 | |a YDX |b eng |c YDX |d OPELS |d OCLCO |d OCLCL |d SFB |d SMC |d N$T |d OCLCF |d OCLCO | ||
| 019 | |a 1515203937 | ||
| 020 | |a 9780323972437 |q (electronic bk.) | ||
| 020 | |a 0323972438 |q (electronic bk.) | ||
| 020 | |z 9780323918152 | ||
| 020 | |z 0323918158 | ||
| 035 | |a (OCoLC)1435616390 |z (OCoLC)1515203937 | ||
| 050 | 4 | |a TP978 | |
| 082 | 0 | 4 | |a 615.6 |2 23/eng/20240611 |1 https://id.oclc.org/worldcat/ddc/E3TwF968xWhtc3dQv3rxRjX3dJ |
| 245 | 0 | 0 | |a Application of gellan gum as a biomedical polymer / |c edited by Amit Kumar Nayak, Md Saquib Hasnain. |
| 260 | |a London : |b Academic Press, |c 2024. | ||
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 588 | 0 | |a Print version record. | |
| 504 | |a Includes bibliographical references and index. | ||
| 505 | 0 | |a Front Cover -- Application of Gellan Gum as a Biomedical Polymer -- Copyright Page -- Contents -- List of contributors -- 1 An overview of gellan gum sources, properties, and its targeted applications -- 1.1 Introduction -- 1.2 Gellan gum: source and chemistry background -- 1.3 Gellan gum properties for diverse drug delivery applications -- 1.4 Gellan gum properties for wound dressing application -- 1.5 Gellan gum properties for cartilage and scaffold application -- 1.6 Gellan gum properties for dentistry application -- 1.6.1 Filler for alveolar space preservation -- 1.6.2 Oral cancer treatment patch -- 1.6.3 Oral candidiasis treatment and prevention -- 1.7 Conclusion -- References -- 2 Impact of environmental conditions on the preparation and functionality of gellan gum -- 2.1 Effect of pH -- 2.1.1 Rheological behavior of gellan gum in aqueous media -- 2.2 Effect of temperature -- 2.3 Effect of types and concentration of ions -- 2.4 Effect of sugars -- 2.5 Gellan's interactions with other biomolecules -- 2.5.1 Gellan-polysaccharide mixtures -- 2.5.1.1 Xanthan/gellan gum -- 2.5.1.2 Sodium alginate/gellan gum -- 2.5.1.3 Carrageenan/gellan gum -- 2.5.1.4 Konjac glucomannan/gellan gum -- 2.5.1.5 Guar/gellan gum -- 2.5.1.6 Pectin/gellan gum -- 2.5.1.7 Chitosan/gellan gum -- 2.5.2 Gellan gum interaction with proteins -- 2.5.2.1 Gelatin/gellan gum -- 2.5.2.2 Whey protein/gellan gum -- 2.6 Effect of degree of acylation -- 2.6.1 High acyl gellan gum -- 2.6.2 Blends of high acyl and deacylated gellan -- 2.6.3 Low acyl gellan gum -- References -- 3 Sol-gel behavior of gellan gum and its applications in biomedical industry -- 3.1 Introduction -- 3.2 Determination of sol-gel transition of gellan gum -- 3.3 Sol-gel behavior of gellan gum -- 3.3.1 Effect of type and concentration of gellan gum on sol-gel behavior. | |
| 505 | 8 | |a 3.3.2 Effect of cation addition on gellan sol-gel behavior -- 3.3.3 Effect of cosolute addition on sol-gel behavior of gellan gum -- 3.3.4 Effect of pH values on sol-gel behavior of gellan gum -- 3.3.5 Effect of temperature on sol-gel behavior of gellan gum -- 3.4 Biomedical applications -- References -- 4 Gelation mechanism of gellan gum for biomedical applications -- 4.1 Introduction -- 4.2 Gelation mechanism -- 4.3 Applications of gellan gum in the biomedical area -- 4.4 Some reviews of research about gellan gum in biomedical applications -- 4.5 Conclusions -- References -- I. Biomedical materials -- 5 Biomedical property of gellan gum -- 5.1 Introduction -- 5.2 Discovery of gellan and structure -- 5.3 Physicochemical properties -- 5.3.1 Size and charge -- 5.3.2 Hydrating and gelling -- 5.3.3 Rheological flow -- 5.3.4 Texture, stability, and mechanical strength -- 5.4 Biomedical properties -- 5.4.1 Absence of toxicity -- 5.4.2 Biocompatibility -- 5.4.3 Biodegradability -- 5.4.4 Limitations and ways forward -- 5.5 Conclusions -- References -- 6 Gellan gum-based biomedical gels -- 6.1 Introduction -- 6.2 Gellan gum-based gels -- 6.3 Biomedical applications -- 6.3.1 Tissue engineering -- 6.3.1.1 Cartilage repair -- 6.3.1.2 Wound healing -- 6.3.1.3 Bone regeneration -- 6.3.1.4 Stem-cells technology -- 6.3.2 Drug delivery -- 6.3.2.1 Oral drug delivery -- 6.3.2.2 Ocular drug delivery -- 6.3.2.3 Nasal drug delivery -- 6.3.2.4 Topical drug delivery -- 6.4 Concluding remarks -- References -- 7 Gellan gum-based hydrogels as useful biomedical material -- 7.1 Introduction -- 7.2 Gellan gum hydrogels -- 7.2.1 Limitations/drawbacks of gellan gum hydrogel -- 7.3 Fabrication strategies for tuning physicochemical properties -- 7.3.1 Gelation temperature -- 7.3.1.1 Introduction of specific functional groups -- 7.3.1.2 Oxidative cleavage. | |
| 505 | 8 | |a 7.3.2 Mechanical performance and degradation behavior -- 7.3.2.1 Introduction of double bonds -- 7.3.2.2 Incorporation of inorganic materials and enzymes -- 7.3.3 Enhancement of biological performance -- 7.3.3.1 Conjugation of gellan gum with bioactive peptides/proteins -- 7.4 Biomedical applications of gellan gum hydrogels -- 7.4.1 Drug delivery -- 7.4.2 Tissue engineering -- 7.4.3 Gellan gum blended with natural polymer hydrogels -- 7.4.3.1 Gellan gum-chitosan loaded with ciprofloxacin for dermal applications -- 7.4.3.2 Gellan gum-chitosan loaded with carboxymethyl for encapsulation of chondrocytes -- 7.4.3.3 Gellan gum-chitosan hydrogels for wound healing -- 7.4.3.4 Gellan gum-grafted chitosan for nasal insert production -- 7.4.3.5 Gellan gum-grafted polyethylenimine for gene delivery -- 7.4.3.6 Polydextrose-based gellan gum in food products -- 7.5 Conclusion -- References -- 8 Gellan gum microspheres and their applications in the biomedical industry -- 8.1 Introduction -- 8.2 Gellan gum applications -- 8.3 Methodologies for the microspheres production -- 8.4 Gellan gum-based microspheres applications -- 8.4.1 Delivery systems -- 8.4.1.1 Nasal formulations -- 8.4.1.2 Oral formulations -- 8.4.2 Tissue engineering -- 8.4.3 Capture strategies of therapeutic biomolecules -- 8.5 Conclusions and future perspectives -- References -- 9 Gellan gum-based nanocomposite hydrogels -- 9.1 Introduction -- 9.2 Synthesis methods and structures of gellan gum hydrogels -- 9.3 Modifications of gellan gum structure -- 9.3.1 Enhancing the gellan gum features via crosslinking techniques -- 9.3.2 Improving the gellan gum properties by using additives -- 9.4 Medical application of gellan gum nanocomposites -- 9.4.1 Drug delivery -- 9.4.2 Tissue engineering -- 9.4.3 Wound dressing and cancer therapy applications -- 9.5 Conclusion -- References. | |
| 505 | 8 | |a 10 Gellan gum based nanosystems for biomedical applications -- 10.1 Introduction -- 10.2 Gellan gum: source, chemistry, and composition -- 10.3 Modification of gellan gum for nanosystem designing -- 10.4 Different nanosystems based on gellan gum -- 10.4.1 Nanoparticles -- 10.4.2 Nanogels -- 10.4.3 Nanoemulsions -- 10.4.4 Liposomes -- 10.4.5 Bionanocomposites -- 10.5 Applications of gellan gum nanosystems -- 10.5.1 Drug delivery -- 10.5.2 Wound healing -- 10.5.3 Tissue engineering -- 10.5.4 Photothermal therapy -- 10.6 Conclusion -- References -- 11 Crosslinked gellan gum for biomedical applications -- 11.1 Introduction -- 11.2 Crosslinked gellan gum in drug delivery -- 11.2.1 Transdermal drug delivery using gellan gum-based systems -- 11.2.2 Gellan gum-based formulations for ocular delivery -- 11.2.3 Gellan gum-based formulations for intranasal delivery -- 11.2.4 Gellan gum-based systems for intravaginal drug delivery -- 11.2.5 Gellan gum-based formulations for oral delivery -- 11.2.6 Gellan gum-based systems for colon delivery -- 11.3 Crosslinked gellan gum in wound healing -- 11.3.1 Film -- 11.3.2 Hydrogels -- 11.4 Conclusion -- References -- II. Biomedical applications -- 12 Gellan gum-based wound dressings -- 12.1 Introduction -- 12.2 Classification of wound dressings -- 12.3 Properties of gellan gum -- 12.4 Uses of gellan gum in wound dressing formulations and their characteristics -- 12.5 Conclusion -- References -- 13 Probiotic encapsulation and delivery using gellan gum -- 13.1 Introduction -- 13.2 Probiotic encapsulation and delivery using gellan gum -- 13.2.1 What is a probiotic? -- 13.2.2 Probiotic microencapsulation techniques -- 13.2.2.1 Emulsion-gelation -- 13.2.2.2 Extrusion-gelation -- 13.2.2.3 Freeze-drying -- 13.2.2.4 Ionic gelation -- 13.3 What do we know to date about probiotic encapsulation with gellan gum?. | |
| 505 | 8 | |a 13.3.1 Capsule functionality -- 13.3.1.1 Protection during processing -- 13.3.1.2 Protection during storage -- 13.3.1.3 Protection during transit through the gastrointestinal tract -- 13.3.1.4 Targeted delivery and preservation of biological effects -- 13.3.2 Coencapsulation: what else can we add? -- 13.3.2.1 Cryoprotectants -- 13.3.2.2 Prebiotics -- 13.3.2.3 Bioactive compounds -- 13.4 Conclusion -- References -- 14 Protein and peptide delivery using gellan gum -- 14.1 Introduction -- 14.1.1 The demand for a pharmaceutical shape -- 14.2 Drug deliverance systems as carriers for biological molecules -- 14.2.1 Proteins and peptides -- 14.2.1.1 Therapeutic proteins -- 14.2.1.2 Challenges in the delivery of therapeutic proteins -- 14.2.1.2.1 Immunogenicity -- 14.2.1.2.2 Brief half-life -- 14.2.1.2.3 The isoelectric point and protein charge -- 14.3 Peptides with modifiable construction -- 14.3.1 Enzyme-reactive peptides -- 14.3.2 pH-reactive peptides -- 14.3.3 Oxidation reduction reactive peptide -- 14.3.4 Thermoreactive peptides -- 14.3.5 Light-reactive peptides -- 14.3.6 Peptides responsive to metallic ions -- 14.4 Physical and chemical features of protein-based medications -- 14.4.1 Molecular scale and weight -- 14.4.2 Hydrophilicity -- 14.4.3 Surface charge -- 14.5 Biologic barriers -- 14.5.1 The pH of biological circumferences -- 14.5.2 Enzymatic obstacles -- 14.5.3 Mucosal obstacles -- 14.5.4 Others -- 14.6 Formulization strategies for noninvasive protein medication deliverance -- 14.6.1 Palatal deliverance -- 14.6.2 Polymer-based formulizations -- 14.6.2.1 Hydrogels -- 14.6.2.2 Nanoparticles -- 14.6.2.3 Redox-activated nanocarriers -- 14.7 Cons and restrictions of protein nanoparticles -- 14.7.1 Proteins are normal polymers -- 14.7.2 Immunogenicity -- 14.7.3 Achieving the right distribution pattern -- 14.7.4 Animal disease. | |
| 520 | |a This book provides a comprehensive examination of the applications of gellan gum as a biomedical polymer. It explores the sources, properties, and chemistry of gellan gum, focusing on its diverse applications in drug delivery, wound dressing, cartilage and scaffold applications, dentistry, and more. The text covers the impact of environmental conditions on gellan gum's functionality and its interactions with other biomolecules. It discusses sol-gel transitions, gelation mechanisms, and the biomedical properties of gellan gum, including its use in hydrogels, microspheres, and nanosystems. The book also addresses the use of gellan gum in nutrient and protein delivery, as well as its potential in tropical medicine. Aimed at researchers and practitioners in the biomedical field, it provides insights into the latest developments and future perspectives of gellan gum in medicine. |7 Generated by AI | ||
| 650 | 0 | |a Gums and resins |x Industrial applications. | |
| 650 | 0 | |a Drug delivery systems. | |
| 650 | 0 | |a Biomedical materials. | |
| 650 | 2 | |a Drug Delivery Systems |0 (DNLM)D016503 | |
| 650 | 6 | |a Systèmes d'administration de médicaments. |0 (CaQQLa)000260397 | |
| 650 | 6 | |a Biomatériaux. |0 (CaQQLa)201-0025723 | |
| 650 | 7 | |a Biomedical materials |2 fast |0 (OCoLC)fst00832586 | |
| 650 | 7 | |a Drug delivery systems |2 fast |0 (OCoLC)fst00898667 | |
| 700 | 1 | |a Nayak, Amit Kumar. | |
| 700 | 1 | |a Hasnain, Md Saquib. | |
| 776 | 0 | 8 | |i Print version: |z 9780323972437 |
| 776 | 0 | 8 | |i Print version: |z 0323918158 |z 9780323918152 |w (OCoLC)1304813420 |
| 776 | 0 | 8 | |i Print version: |z 9780323918152 |
| 776 | 0 | 8 | |i Print version: |z 0323918158 |
| 856 | 4 | 0 | |3 ScienceDirect |u https://www.sciencedirect.com/science/book/9780323918152 |