Application of gellan gum as a biomedical polymer /

This book provides a comprehensive examination of the applications of gellan gum as a biomedical polymer. It explores the sources, properties, and chemistry of gellan gum, focusing on its diverse applications in drug delivery, wound dressing, cartilage and scaffold applications, dentistry, and more....

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Άλλοι συγγραφείς:	Nayak, Amit Kumar, Hasnain, Md Saquib
Μορφή:	Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:	Αγγλικά
Έκδοση:	London : Academic Press, 2024.
Θέματα:	Gums and resins > Industrial applications. Drug delivery systems. Biomedical materials. Drug Delivery Systems Systèmes d'administration de médicaments. Biomatériaux. Biomedical materials Drug delivery systems
Διαθέσιμο Online:	ScienceDirect
Ετικέτες:	Προσθήκη ετικέτας Δεν υπάρχουν, Καταχωρήστε ετικέτα πρώτοι!

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Front Cover
Application of Gellan Gum as a Biomedical Polymer
Copyright Page
Contents
List of contributors
1 An overview of gellan gum sources, properties, and its targeted applications
1.1 Introduction
1.2 Gellan gum: source and chemistry background
1.3 Gellan gum properties for diverse drug delivery applications
1.4 Gellan gum properties for wound dressing application
1.5 Gellan gum properties for cartilage and scaffold application
1.6 Gellan gum properties for dentistry application
1.6.1 Filler for alveolar space preservation
1.6.2 Oral cancer treatment patch
1.6.3 Oral candidiasis treatment and prevention
1.7 Conclusion
References
2 Impact of environmental conditions on the preparation and functionality of gellan gum
2.1 Effect of pH
2.1.1 Rheological behavior of gellan gum in aqueous media
2.2 Effect of temperature
2.3 Effect of types and concentration of ions
2.4 Effect of sugars
2.5 Gellan's interactions with other biomolecules
2.5.1 Gellan-polysaccharide mixtures
2.5.1.1 Xanthan/gellan gum
2.5.1.2 Sodium alginate/gellan gum
2.5.1.3 Carrageenan/gellan gum
2.5.1.4 Konjac glucomannan/gellan gum
2.5.1.5 Guar/gellan gum
2.5.1.6 Pectin/gellan gum
2.5.1.7 Chitosan/gellan gum
2.5.2 Gellan gum interaction with proteins
2.5.2.1 Gelatin/gellan gum
2.5.2.2 Whey protein/gellan gum
2.6 Effect of degree of acylation
2.6.1 High acyl gellan gum
2.6.2 Blends of high acyl and deacylated gellan
2.6.3 Low acyl gellan gum
References
3 Sol-gel behavior of gellan gum and its applications in biomedical industry
3.1 Introduction
3.2 Determination of sol-gel transition of gellan gum
3.3 Sol-gel behavior of gellan gum
3.3.1 Effect of type and concentration of gellan gum on sol-gel behavior.
3.3.2 Effect of cation addition on gellan sol-gel behavior
3.3.3 Effect of cosolute addition on sol-gel behavior of gellan gum
3.3.4 Effect of pH values on sol-gel behavior of gellan gum
3.3.5 Effect of temperature on sol-gel behavior of gellan gum
3.4 Biomedical applications
References
4 Gelation mechanism of gellan gum for biomedical applications
4.1 Introduction
4.2 Gelation mechanism
4.3 Applications of gellan gum in the biomedical area
4.4 Some reviews of research about gellan gum in biomedical applications
4.5 Conclusions
References
I. Biomedical materials
5 Biomedical property of gellan gum
5.1 Introduction
5.2 Discovery of gellan and structure
5.3 Physicochemical properties
5.3.1 Size and charge
5.3.2 Hydrating and gelling
5.3.3 Rheological flow
5.3.4 Texture, stability, and mechanical strength
5.4 Biomedical properties
5.4.1 Absence of toxicity
5.4.2 Biocompatibility
5.4.3 Biodegradability
5.4.4 Limitations and ways forward
5.5 Conclusions
References
6 Gellan gum-based biomedical gels
6.1 Introduction
6.2 Gellan gum-based gels
6.3 Biomedical applications
6.3.1 Tissue engineering
6.3.1.1 Cartilage repair
6.3.1.2 Wound healing
6.3.1.3 Bone regeneration
6.3.1.4 Stem-cells technology
6.3.2 Drug delivery
6.3.2.1 Oral drug delivery
6.3.2.2 Ocular drug delivery
6.3.2.3 Nasal drug delivery
6.3.2.4 Topical drug delivery
6.4 Concluding remarks
References
7 Gellan gum-based hydrogels as useful biomedical material
7.1 Introduction
7.2 Gellan gum hydrogels
7.2.1 Limitations/drawbacks of gellan gum hydrogel
7.3 Fabrication strategies for tuning physicochemical properties
7.3.1 Gelation temperature
7.3.1.1 Introduction of specific functional groups
7.3.1.2 Oxidative cleavage.
7.3.2 Mechanical performance and degradation behavior
7.3.2.1 Introduction of double bonds
7.3.2.2 Incorporation of inorganic materials and enzymes
7.3.3 Enhancement of biological performance
7.3.3.1 Conjugation of gellan gum with bioactive peptides/proteins
7.4 Biomedical applications of gellan gum hydrogels
7.4.1 Drug delivery
7.4.2 Tissue engineering
7.4.3 Gellan gum blended with natural polymer hydrogels
7.4.3.1 Gellan gum-chitosan loaded with ciprofloxacin for dermal applications
7.4.3.2 Gellan gum-chitosan loaded with carboxymethyl for encapsulation of chondrocytes
7.4.3.3 Gellan gum-chitosan hydrogels for wound healing
7.4.3.4 Gellan gum-grafted chitosan for nasal insert production
7.4.3.5 Gellan gum-grafted polyethylenimine for gene delivery
7.4.3.6 Polydextrose-based gellan gum in food products
7.5 Conclusion
References
8 Gellan gum microspheres and their applications in the biomedical industry
8.1 Introduction
8.2 Gellan gum applications
8.3 Methodologies for the microspheres production
8.4 Gellan gum-based microspheres applications
8.4.1 Delivery systems
8.4.1.1 Nasal formulations
8.4.1.2 Oral formulations
8.4.2 Tissue engineering
8.4.3 Capture strategies of therapeutic biomolecules
8.5 Conclusions and future perspectives
References
9 Gellan gum-based nanocomposite hydrogels
9.1 Introduction
9.2 Synthesis methods and structures of gellan gum hydrogels
9.3 Modifications of gellan gum structure
9.3.1 Enhancing the gellan gum features via crosslinking techniques
9.3.2 Improving the gellan gum properties by using additives
9.4 Medical application of gellan gum nanocomposites
9.4.1 Drug delivery
9.4.2 Tissue engineering
9.4.3 Wound dressing and cancer therapy applications
9.5 Conclusion
References.
10 Gellan gum based nanosystems for biomedical applications
10.1 Introduction
10.2 Gellan gum: source, chemistry, and composition
10.3 Modification of gellan gum for nanosystem designing
10.4 Different nanosystems based on gellan gum
10.4.1 Nanoparticles
10.4.2 Nanogels
10.4.3 Nanoemulsions
10.4.4 Liposomes
10.4.5 Bionanocomposites
10.5 Applications of gellan gum nanosystems
10.5.1 Drug delivery
10.5.2 Wound healing
10.5.3 Tissue engineering
10.5.4 Photothermal therapy
10.6 Conclusion
References
11 Crosslinked gellan gum for biomedical applications
11.1 Introduction
11.2 Crosslinked gellan gum in drug delivery
11.2.1 Transdermal drug delivery using gellan gum-based systems
11.2.2 Gellan gum-based formulations for ocular delivery
11.2.3 Gellan gum-based formulations for intranasal delivery
11.2.4 Gellan gum-based systems for intravaginal drug delivery
11.2.5 Gellan gum-based formulations for oral delivery
11.2.6 Gellan gum-based systems for colon delivery
11.3 Crosslinked gellan gum in wound healing
11.3.1 Film
11.3.2 Hydrogels
11.4 Conclusion
References
II. Biomedical applications
12 Gellan gum-based wound dressings
12.1 Introduction
12.2 Classification of wound dressings
12.3 Properties of gellan gum
12.4 Uses of gellan gum in wound dressing formulations and their characteristics
12.5 Conclusion
References
13 Probiotic encapsulation and delivery using gellan gum
13.1 Introduction
13.2 Probiotic encapsulation and delivery using gellan gum
13.2.1 What is a probiotic?
13.2.2 Probiotic microencapsulation techniques
13.2.2.1 Emulsion-gelation
13.2.2.2 Extrusion-gelation
13.2.2.3 Freeze-drying
13.2.2.4 Ionic gelation
13.3 What do we know to date about probiotic encapsulation with gellan gum?.
13.3.1 Capsule functionality
13.3.1.1 Protection during processing
13.3.1.2 Protection during storage
13.3.1.3 Protection during transit through the gastrointestinal tract
13.3.1.4 Targeted delivery and preservation of biological effects
13.3.2 Coencapsulation: what else can we add?
13.3.2.1 Cryoprotectants
13.3.2.2 Prebiotics
13.3.2.3 Bioactive compounds
13.4 Conclusion
References
14 Protein and peptide delivery using gellan gum
14.1 Introduction
14.1.1 The demand for a pharmaceutical shape
14.2 Drug deliverance systems as carriers for biological molecules
14.2.1 Proteins and peptides
14.2.1.1 Therapeutic proteins
14.2.1.2 Challenges in the delivery of therapeutic proteins
14.2.1.2.1 Immunogenicity
14.2.1.2.2 Brief half-life
14.2.1.2.3 The isoelectric point and protein charge
14.3 Peptides with modifiable construction
14.3.1 Enzyme-reactive peptides
14.3.2 pH-reactive peptides
14.3.3 Oxidation reduction reactive peptide
14.3.4 Thermoreactive peptides
14.3.5 Light-reactive peptides
14.3.6 Peptides responsive to metallic ions
14.4 Physical and chemical features of protein-based medications
14.4.1 Molecular scale and weight
14.4.2 Hydrophilicity
14.4.3 Surface charge
14.5 Biologic barriers
14.5.1 The pH of biological circumferences
14.5.2 Enzymatic obstacles
14.5.3 Mucosal obstacles
14.5.4 Others
14.6 Formulization strategies for noninvasive protein medication deliverance
14.6.1 Palatal deliverance
14.6.2 Polymer-based formulizations
14.6.2.1 Hydrogels
14.6.2.2 Nanoparticles
14.6.2.3 Redox-activated nanocarriers
14.7 Cons and restrictions of protein nanoparticles
14.7.1 Proteins are normal polymers
14.7.2 Immunogenicity
14.7.3 Achieving the right distribution pattern
14.7.4 Animal disease.

Application of gellan gum as a biomedical polymer /

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