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Spirooxindole : chemistry, synthesis, characterization and biological significance /

This book, edited by Gautam Patel, Vraj R. Shah, Tuan Anh Nguyen, and Kalim Deshmukh, offers a comprehensive exploration of spirooxindole chemistry, focusing on synthesis and biological significance. It delves into various synthetic methods, including cycloaddition reactions and regioselective synth...

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Bibliographic Details
Format: eBook
Language:English
Published: [S.l.] : Elsevier, 2024.
Subjects:
Oxindoles.
Oxindoles
Online Access:ScienceDirect
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Table of Contents:
  • Front Cover
  • Spirooxindole
  • Copyright Page
  • Contents
  • List of contributors
  • About the editors
  • Preface
  • 1 Synthesis of spirooxindoles by [3+2] cycloadditions
  • 1.1 Introduction
  • 1.2 Cycloadditions of isatin-based dipolarophiles
  • 1.3 [3+2] Cycloadditions of isatin-derived 1,3-dipoles
  • 1.4 Cycloadditions of isatin-derived 1,3-dipoles and dipolarophiles for dispirooxindoles
  • 1.5 Intramolecular [3+2] cycloadditions
  • 1.6 Summary
  • References
  • 2 Synthesis of spirooxindoles under ultrasonication
  • 2.1 Introduction
  • 2.2 Construction of three member ring on C-3 carbon of oxindole
  • 2.2.1 Synthesis of oxirane annulated spirooxindoles
  • 2.3 Construction of five member ring on C-3 carbon oxindole
  • 2.3.1 Synthesis of pyrrolidine annulated spirooxindoles
  • 2.3.2 Synthesis of thiazolidinone ring annulated spirooxindoles
  • 2.3.3 Synthesis of oxathiolanes ring annulated spirooxindoles
  • 2.3.4 Synthesis of pyrazol ring annulated spirooxindoles
  • 2.4 Construction of six member ring on C-3 carbon of oxindoles
  • 2.4.1 Synthesis of pyran annulated spirooxindoles
  • 2.4.1.1 Three-component reactions
  • 2.4.1.2 Four component reactions
  • 2.4.2 Synthesis of pyridine annulated spirooxindoles
  • 2.4.3 Synthesis of naphthalene annulated spirooxindoles
  • 2.4.4 Synthesis of quinazolinones annulated spirooxindoles
  • 2.4.5 Synthesis of thiazine annulated spirooxindoles
  • 2.4.6 Synthesis of oxazine annulated spirooxindoles
  • 2.5 Construction of seven member ring on C-3 carbon
  • 2.5.1 Synthesis of thiazepine ring annulated spirooxindoles
  • 2.5.2 Synthesis of diazepine ring annulated spirooxindoles
  • 2.6 Conclusion
  • References
  • 3 Organocatalyzed cycloaddition of N-2,2,2-trifluoroethylisatin ketimines for synthesis of CF3-containing spirooxindoles
  • 3.1 Introduction
  • 3.2 Organocatalyzed asymmetric [3+2] cycloaddition reaction of N-2,2,2-trifluoroethylisatin ketimines
  • 3.2.1 Synthesis of CF3-containing monospiroxidindoles
  • 3.2.1.1 Asymmetric [3+2] cycloaddition reactions with chained conjugated alkenes
  • 3.2.1.2 Asymmetric [3+2] cycloaddition reactions with exocyclic olefins
  • 3.2.2 Synthesis of CF3-containing dispiroxidindoles
  • 3.2.2.1 Asymmetric [3+2] cycloaddition reactions with exocyclic olefins
  • 3.2.2.2 Asymmetric [3+2] cycloaddition reactions with 3-metheneindolinones
  • 3.2.3 Synthesis of CF3-containing pyrrolidine-fused spirocyclic dihydro-benzoheterocyclic compounds
  • 3.2.4 Synthesis of other CF3-containing polycyclic compounds
  • 3.3 Organocatalyzed asymmetric [4+3] cycloaddition reaction of N-2,2,2-trifluoroethylisatin ketimines
  • 3.4 Conclusions
  • References
  • 4 Regio- and stereoselective synthesis of spirooxindole scaffold
  • 4.1 Introduction
  • 4.1.1 Network analysis about spirooxindoles
  • 4.2 Regio- and stereoselective synthesis of spirooxindole scaffolds

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