Biochemical and molecular pharmacology in drug discovery /
This comprehensive book, 'Biochemical and Molecular Pharmacology in Drug Discovery,' edited by Mithun Rudrapal, Chukwuebuka Egbuna, and William C. C Ho, provides an in-depth exploration of the biochemical and molecular aspects critical to the process of drug discovery. It covers a wide arr...
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| Формат: | eКнига |
|---|---|
| Язык: | английский |
| Опубликовано: |
[S.l.] :
Elsevier,
2024.
|
| Серии: | Drug Discovery Update Series.
|
| Предметы: | |
| Online-ссылка: | ScienceDirect |
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| 082 | 0 | 4 | |a 615.1 |2 23/eng/20240710 |1 https://id.oclc.org/worldcat/ddc/E3WX9Cm8hFQyxyGYH9X9cwbqQP |
| 245 | 0 | 0 | |a Biochemical and molecular pharmacology in drug discovery / |c edited by Mithun Rudrapal, Chukwuebuka Egbuna and William C. Cho. |
| 260 | |a [S.l.] : |b Elsevier, |c 2024. | ||
| 300 | |a 1 online resource | ||
| 490 | 1 | |a Drug Discovery Update Series | |
| 505 | 0 | |a Front Cover -- BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY -- BIOCHEMICAL AND MOLECULAR PHARMACOLOGY IN DRUG DISCOVERY -- Copyright -- Contents -- Contributors -- I -- Biochemical and molecular aspects -- 1 -- Structures and functions of biomolecules -- 1. Introduction -- 1.1 About biomolecules -- 1.2 Carbohydrates -- 1.2.1 Structure of carbohydrates -- 1.2.2 Functions of carbohydrates -- 1.3 Proteins -- 1.3.1 Structure of proteins -- 1.3.2 Functions of proteins -- 1.4 Lipids -- 1.4.1 Structure of lipids -- 1.4.2 Functions of lipids -- 1.5 Nucleic acids | |
| 505 | 8 | |a 1.5.1 Structure of nucleic acids -- 1.5.1.1 Types of RNA -- 1.5.2 Functions of nucleic acids -- 2. Structure Activity Relationship (SAR) -- 2.1 Need for the SAR study -- 3. Ligands -- 3.1 Classification of ligands -- 4. Receptors -- 4.1 Classification of receptors -- 4.2 Some of the examples of the receptors acting as therapeutic targets -- 5. Conclusion -- References -- 2 -- Pharmacokinetics and pharmacodynamics -- 1. Introduction -- 1.1 Sources of drugs -- 1.2 Drug nomenclature -- 1.3 Drug classification -- 1.4 Drug transport through cell membranes -- 1.4.1 Simple diffusion -- 1.4.2 Filtration | |
| 505 | 8 | |a 1.4.3 Carrier mediated -- 1.4.4 Endocytosis -- 2. Pharmacokinetics (ADME) -- 2.1 Absorption -- 2.1.1 Bioavailability -- 2.1.1.1 Factors affecting oral bioavailability -- 2.1.2 Factors influencing digestive resorption -- 2.1.2.1 Pharmaceutical form -- 2.1.2.2 pH, PKa, log P, molecular weight -- 2.1.2.3 Metabolism in the digestive tract, gastric secretion and food bowl -- 2.1.2.4 First pass effect -- 2.1.2.5 Other factors -- 2.2 Distribution -- 2.2.1 Patterns of distribution -- 2.2.2 Factors affecting distribution of drugs -- 2.2.3 Apparent volume of distribution (Vd) | |
| 505 | 8 | |a 2.3 Metabolism (biotransformation) -- 2.3.1 Site of metabolism -- 2.3.2 Types of metabolic reactions -- 2.3.3 Enzymes responsible for biotransformation -- 2.3.4 Factors affecting hepatic microsomal enzyme activity -- 2.4 Excretion -- 2.4.1 Clearance -- 2.5 Fundamental principles of pharmacokinetics -- 2.5.1 Plasma half-life (t1/2) -- 2.5.2 Loading dose -- 2.5.3 Maintenance dose -- 2.5.4 Methods used to prolong duration of action of drugs -- 3. Pharmacodynamics -- 3.1 Possible mechanisms of action of drugs -- 3.2 Definition of receptors -- 3.3 Affinity -- 3.4 Efficacy -- 3.5 Potency | |
| 505 | 8 | |a 3.6 The amount of response -- 3.7 Relation between concentration and response -- 3.7.1 Dose-response curve of drugs -- 3.7.2 Types of ligands -- 3.7.3 Types of antagonists -- 3.7.4 Non-competitive block types -- 3.7.5 Types of receptors and signal transduction mechanism -- 4. Conclusion -- References -- 3 -- Overview of drugs and drug targets -- 1. Introduction -- 1.1 Drug development process -- 1.2 Discovery -- 1.2.1 Target identification and validation -- 1.2.2 Assay development -- 1.2.3 Lead identification -- 1.2.4 Lead optimization -- 1.3 Development -- 1.3.1 Predevelopment | |
| 520 | |a This comprehensive book, 'Biochemical and Molecular Pharmacology in Drug Discovery,' edited by Mithun Rudrapal, Chukwuebuka Egbuna, and William C. C Ho, provides an in-depth exploration of the biochemical and molecular aspects critical to the process of drug discovery. It covers a wide array of topics including the structures and functions of biomolecules, drug targets and mechanisms, molecular cloning, and drug receptor interactions. The text also delves into enzyme roles, RNA modifications, molecular pharmacology applications, and the integration of omics technologies and big data in drug discovery. It is designed for professionals and researchers in the field of pharmacology and drug development, offering insights into current trends, challenges, and future directions. The book serves as a valuable resource for understanding the complex processes involved in modern drug discovery, with a focus on personalized medicine and novel therapeutic strategies. |7 Generated by AI | ||
| 650 | 0 | |a Pharmacology. | |
| 650 | 0 | |a Molecular pharmacology. | |
| 650 | 2 | |a Pharmacology |0 (DNLM)D010600 | |
| 650 | 6 | |a Pharmacologie. |0 (CaQQLa)201-0007219 | |
| 650 | 6 | |a Pharmacologie moléculaire. |0 (CaQQLa)201-0165543 | |
| 650 | 7 | |a pharmacology. |2 aat |0 (CStmoGRI)aat300137970 | |
| 650 | 7 | |a Molecular pharmacology |2 fast |0 (OCoLC)fst01024822 | |
| 650 | 7 | |a Pharmacology |2 fast |0 (OCoLC)fst01060259 | |
| 776 | 0 | 8 | |i Print version: |z 0443160139 |z 9780443160134 |w (OCoLC)1390915323 |
| 830 | 0 | |a Drug Discovery Update Series. | |
| 856 | 4 | 0 | |3 ScienceDirect |u https://www.sciencedirect.com/science/book/9780443160134 |