Multitasking molecular chaperone Hsp60 : structure, function, and impact on health and disease /
The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and...
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| Kolejni autorzy: | , , |
|---|---|
| Format: | Elektroniczne E-book |
| Język: | angielski |
| Wydane: |
London, U.K. ; San Diego, CA :
Academic Press,
[2025]
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| Hasła przedmiotowe: | |
| Dostęp online: | ScienceDirect |
| Etykiety: |
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| 001 | on1463663460 | ||
| 003 | OCoLC | ||
| 005 | 20260915095212.0 | ||
| 006 | m o d | ||
| 007 | cr |n||||||||| | ||
| 008 | 241026s2025 enk ob 001 0 eng d | ||
| 040 | |a YDX |b eng |e rda |e pn |c YDX |d OPELS |d OCLCO |d EMU |d OCLCO |d OCLCQ |d OCLCL |d SFB |d OCLCF |d OCLCO | ||
| 020 | |a 9780443239977 |q (electronic bk.) | ||
| 020 | |a 0443239975 |q (electronic bk.) | ||
| 020 | |z 9780443239960 |q (print) | ||
| 020 | |z 0443239967 |q (print) | ||
| 035 | |a (OCoLC)1463663460 | ||
| 050 | 4 | |a QP552.M64 | |
| 082 | 0 | 4 | |a 572/.6 |2 23/eng/20241113 |1 https://id.oclc.org/worldcat/ddc/E3GyxVtG98FMGK6kPTRq7XkCGX |
| 245 | 0 | 0 | |a Multitasking molecular chaperone Hsp60 : |b structure, function, and impact on health and disease / |c edited by Francesco Cappello, Anatomy and Histology, University of Palermo, Palermo, Italy; Everly Conway de Macario, School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland, United States; Alberto J. L. Macario, School of Medicine, University of Maryland at Baltimore, Baltimore, Maryland, United States. |
| 246 | 3 | |a Multitasking molecular chaperone heat shock protein 60 | |
| 264 | 1 | |a London, U.K. ; |a San Diego, CA : |b Academic Press, |c [2025] | |
| 300 | |a 1 online resource | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a The book covers various areas of medicine in which Hsp60 chaperonopathies have been identified. Various chapters discuss the Hsp60 structure, localization, functions, and participation in disease mechanisms both genetic and acquired, focusing on humans but also presenting data obtained from pro- and eukaryotic experimental models. The main goal is to provide information accessible to all healthcare professionals in a way that can be understood by nonspecialists and that would stimulate clinical and pathological detection of Hsp60 chaperonopathies. Molecular mechanisms are briefly described with the purpose of illuminating roads toward accurate diagnosis, treatment, and patient monitoring. Consequently, the possibility of developing/applying chaperonotherapy centered on Hsp60, as a therapeutic tool or target, is analyzed in many sections of this book, across a variety of medical specialties. Over the last several years, the importance of the CS as a physiological system has been brought to prominence and its roles in health and disease made clear. The molecular chaperones, including Hsp60, are the key components of the CS that are typically cytoprotective, but they can also be etiopathogenic factors, causing diseases named chaperonopathies. | ||
| 588 | |a Description based on resource, viewed January 3, 2025. | ||
| 505 | 8 | |a Front Cover -- The Multitasking Molecular Chaperone Hsp60 -- The Multitasking Molecular Chaperone Hsp60: Structure, Function, and Impact on Health and Disease -- Copyright -- Contents -- Contributors -- Preface -- One -- The chaperone system and its diseases: Introductory overview focusing on Hsp60 -- 1. The chaperone system -- 2. The chaperonopathies -- 3. Hsp60 -- 4. Components and properties of the CS -- 5. Mapping the CS components in tissues and cells -- 6. The chapters -- References -- Two -- Physical and biochemical properties of the molecular chaperone Hsp60 -- 1. Hsp60, a member of the chaperone system -- 2. Oligomeric structure and allosteric states -- 3. Structural diversity of Hsp60 with implications for pathology -- 4. Further comments on Hsp60 functional diversity -- 5. Hsp60 post-translational modifications -- 5.1 Acetylation -- 5.2 Nitration and S-nitrosylation -- 5.3 Phosphorylation -- Acknowledgments -- References -- Three -- The spectrum of human Hsp60 genetic variants and associated chaperonopathies -- 1. Introduction. Human Hsp60 chaperonin: origin, and physiological and physiopathological roles -- 2. Chaperonopathies and Hsp60-associated chaperonopathies -- 3. Hsp60 genetic chaperonopathies affecting the nervous system |7 Generated by AI | |
| 650 | 0 | |a Heat shock proteins. | |
| 650 | 0 | |a Molecular chaperones. | |
| 650 | 6 | |a Molécules chaperonnes. |0 (CaQQLa)201-0249100 | |
| 650 | 6 | |a Protéines de choc thermique. |0 (CaQQLa)201-0121279 | |
| 650 | 7 | |a Heat shock proteins |2 fast |0 (OCoLC)fst00953977 | |
| 650 | 7 | |a Molecular chaperones |2 fast |0 (OCoLC)fst01024760 | |
| 700 | 1 | |a Cappello, Francesco, |e editor. |1 https://id.oclc.org/worldcat/entity/E39PBJwtjjG7CQ8Tc94DXTQjG3 | |
| 700 | 1 | |a Conway de Macario, Everly, |e editor. |1 https://id.oclc.org/worldcat/entity/E39PCjFgwKBhjKwV3kX4Rp94FX | |
| 700 | 1 | |a Macario, Alberto J. L., |e editor. |1 https://id.oclc.org/worldcat/entity/E39PCjFX3k9b4WWxt433fwDbcX | |
| 776 | 0 | 8 | |c Original |z 0443239967 |z 9780443239960 |w (OCoLC)1436908782 |
| 856 | 4 | 0 | |3 ScienceDirect |u https://www.sciencedirect.com/science/book/9780443239960 |