Mitophagy in health and disease : mechanisms, health implications, and therapeutic opportunities /
Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specif...
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| Format: | Elektronisch E-Book |
| Sprache: | Englisch |
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London :
Academic Press,
[2025]
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| Online-Zugang: | ScienceDirect |
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| 020 | |z 9780443152603 | ||
| 035 | |a (OCoLC)1477813408 | ||
| 050 | 4 | |a QP90.4 | |
| 082 | 0 | 4 | |a 571.7/5 |2 23/eng/20241209 |1 https://id.oclc.org/worldcat/ddc/E49qjtpDxQYhQBvk79yM83FkfD |
| 245 | 0 | 0 | |a Mitophagy in health and disease : |b mechanisms, health implications, and therapeutic opportunities / |c edited by John J. Lemasters. |
| 264 | 1 | |a London : |b Academic Press, |c [2025] | |
| 300 | |a 1 online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 520 | |a Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention. This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ScienceDirect, viewed December 9, 2024). | |
| 505 | 0 | |a Front Cover -- Mitophagy in Health and Disease -- Copyright Page -- Contents -- List of contributors -- About the editor -- Preface -- 1 The invitation -- 2 Why edit this book? -- 3 The contents -- 1 PINK1-Parkin quality control mitophagy pathway in Parkinson's disease -- Introduction -- Parkin, PINK1, and Parkinson's disease -- Discovery of a PINK1-Parkin stress-responsive quality control pathway -- Mechanism of PINK1-Parkin stress response pathway -- Step 1: PINK1 adopts an active conformation on the OMM following mitochondrial import failure -- PINK1 import and proteolysis in healthy mitochondria -- PINK1 sorting to the OMM and activation following mitochondrial import block -- Step 2: Parkin activation by PINK1 -- Step 3: activated Parkin ubiquitinates OMM proteins in the vicinity of PINK1 -- Step 4: ubiquitinated mitochondria are degraded by mitophagy -- Mitophagy in physiologic contexts -- Mitophagy in mammalian neurons -- Mito QC in the mitochondrial fission-fusion cycle -- PINK1-Parkin mitophagy in Drosophila -- PINK1-Parkin pathway in mice -- Therapeutic development -- Enhancing PINK1 activity -- Enhancing Parkin activity -- Other enhancers of PINK1-Parkin mitophagy -- Perspective on the therapeutic potential PINK1-Parkin pathway modulation -- Conclusion -- References -- 2 Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions -- Introduction -- Ubiquitin-dependent and -independent pathways of mitophagy -- BCL2 family protein-mediated mitophagy -- BNIP3-mediated mitophagy -- BNIP3L-mediated mitophagy -- BCL2L13-mediated mitophagy -- FUNDC1-mediated mitophagy -- FKBP8-mediated mitophagy -- PHB2-mediated mitophagy -- NIPSNAP1- and NIPSNAP2-mediated mitophagy -- Lipids in mitophagy -- Cardiolipin -- Ceramide -- Connection of ubiquitin-dependent and -independent mitophagy -- Conclusion and perspectives -- References. | |
| 505 | 8 | |a 3 Role of AMPK/ULK1 signaling in mitophagy -- Abbreviations -- Introduction -- Mitophagy: a brief overview of molecular mechanisms -- Structure, subcellular localization, and regulation mechanisms of AMPK -- Molecular structure and activation of AMPK -- Subcellular localization of AMPK -- AMPK signaling in the cytoplasm -- AMPK signaling in the nucleus -- Lysosomes as a crucial hub to mediate AMPK activation and signaling -- Role of AMPK at the endoplasmic reticulum -- Mitochondrial localization of AMPK -- AMPK signaling in the functional crosstalk between mitochondrial dynamics and mitophagy -- Role of the AMPK/ULK1 axis in regulation of the mitophagy cascade -- Concluding remarks -- References -- 4 Mitochondrial proteases -- Abbreviations -- Mitochondrial protease network -- Mitochondrial processing peptidases -- Oligopeptidases -- Quality control proteases -- i-AAA and m-AAA -- LonP -- ClpXP -- PARL, HTRA2, and OMA1 -- The mitochondrial unfolded protein response (mtUPR) -- Mitochondrial proteases as emerging pharmacological targets -- Concluding remarks -- References -- Further reading -- 5 The mitochondrial unfolded protein response in health and disease -- Abbreviations -- Introduction -- Activation and regulation of the mitochondrial stress response (UPRmt) -- UPRmt activation in Caenorhabditis elegans -- UPRmt activation in mammals -- Chromatin remodeling and UPRmt activation -- Noncanonical pathways that mediate a mitochondrial stress response in mammals -- UPRmt sirtuin axis -- The estrogen receptor alpha axis -- UPRmt and the integrated stress response -- Effects of UPRmt activation in health and disease -- UPRmt and aging -- UPRmt and cardiovascular diseases -- UPRmt and cancer -- UPRmt and neurodegenerative diseases -- UPRmt and mitochondrial diseases -- Prolonged activation of the UPRmt. | |
| 505 | 8 | |a Mitochondrial stress response and mitophagy in recovery of the mitochondrial network -- References -- 6 Mitochondria-derived vesicles: from quality control to inflammation and extracellular vesicles -- Abbreviations -- Introduction -- Mitochondrial quality control -- Mitochondria-derived vesicles -- Mechanisms of MDV formation -- The roles of MDVs in inflammation -- Release of mitochondrial content within extracellular vesicles -- Nature of the mitochondrial content within EVs -- Roles of mitoEVs -- Conclusion -- References -- 7 Molecular regulation of mitochondrial turnover by exercise: tissue adaptation through mitochondrial biogenesis and mitophagy -- Introduction -- Skeletal muscle form and function: important considerations -- Effect of exercise on skeletal muscle mitochondria turnover -- Mechanisms of exercise-mediated mitochondrial biogenesis and mitophagy -- Energy sensor AMPK regulates exercise-induced mitochondrial biogenesis and mitophagy -- Contraction-induced calcium release activates mitochondrial biogenesis and mitophagy -- Exercise-induced ROS signaling promotes mitochondrial turnover in skeletal muscle -- Effect of exercise on mitochondrial biogenesis and mitophagy in other tissues -- Conclusion -- References -- 8 Role of mitophagy and mitochondria in aging and cellular senescence -- List of abbreviations -- Introduction -- Mitochondrial DNA, mitochondrial function, and aging -- Mitochondrial dynamics and aging -- Mitochondrial dysfunction, ROS production, and aging -- Mitochondrial dysfunction, sirtuins, and aging -- Mitophagy and aging -- Mitophagy and cell senescence -- Mitophagy, immunity, and aging -- Mitophagy, neurodegeneration, and aging -- Mitophagy and cardiac aging -- Mitophagy and oocyte aging -- Conclusions -- References -- 9 Mitophagy in erythropoiesis -- Abbreviations -- Introduction. | |
| 505 | 8 | |a Mitochondria clearance and normal red blood cell maturation -- Mitophagy relevance during erythroid maturation -- Mitophagy can be conducted by different molecular pathways -- Mitophagy regulation in erythropoiesis -- Mitophagy associated to hematological disorders -- Concluding remarks -- References -- 10 The dual role of mitophagy in cancer and its targeting for effective anticancer therapy -- Abbreviations -- Introduction -- Brief insights into mitophagy mechanisms -- Role of mitophagy in cancer -- Mitophagy in tumor suppression -- Metabolic reprogramming -- Regulation of cell proliferation and cell death -- Maintenance of oxidative stress -- Targeting inflammasome activation -- Mitophagy in tumor growth and progression -- Maintenance of mitochondrial homeostasis in cancer cells -- Promotion of cancer cell survival and therapy resistance -- Maintenance of cancer stem cells -- Therapeutic targeting of mitophagy for effective anticancer strategy -- Conclusion -- References -- 11 Mitophagy and neurodegenerative disease -- Abbreviations -- Introduction -- Mitophagy in AD -- Mitophagy in PD -- Mitophagy in HD -- Mitophagy in ALS -- Mitophagy in stroke -- Cerebellar atrophy -- Mitophagy as a potential therapeutic target for neurodegenerative disease -- Small molecules targeting PINK1/Parkin -- Therapeutic targets on other mitophagic pathways -- Therapeutic targets on antioxidative stress -- Therapeutic targets on antiinflammation -- Physical effects -- Future perspectives -- References -- 12 The antiaging role of mitophagy -- Abbreviations -- Introduction -- The molecular pathways of mitophagy -- The phosphatase and tensin homolog-induced putative kinase 1/Parkin pathway -- Receptor-mediated mitophagy -- Alterations in mitophagy during aging and age-related diseases -- Alterations in mitophagy during aging. | |
| 505 | 8 | |a Alterations in mitophagy of age-related diseases -- The antiaging role of mitophagy -- Compounds that act as mitophagy modulators -- Calorie restriction and exercise promote longevity -- Conclusions -- References -- 13 Compromised mitophagy in aging and neurodegenerative diseases -- Abbreviations -- Introduction -- Mitophagy -- PINK-Parkin-dependent mitophagy -- PINK-Parkin-independent mitophagy -- Receptor-mediated mitophagy -- Ubiquitin ligase-mediated mitophagy -- Compromised mitophagy in aging -- Compromised mitophagy in Alzheimer's disease -- Compromised mitophagy in Parkinson's disease -- Compromised mitophagy in amyotrophic lateral sclerosis diseaset? -- Mitophagy in Huntington's disease -- Concluding remarks -- References -- 14 Mitophagy inducers as potential therapeutic agents -- Why inducing mitophagy is a promising medical strategy -- A detailed discussion of the mechanisms of action of five well-characterized inducers of mitophagy -- Berberine as an inducer of mitophagy -- Resveratrol as an inducer of mitophagy -- Rapamycin as an inducer of mitophagy -- Spermidine as an inducer of mitophagy -- Metformin as an inducer of mitophagy -- Behavior of mitophagy inducers in animal models -- Other benefits and safety concerns of mitophagy inducers -- Other potential inducers of mitophagy -- Concluding remarks -- References -- 15 Mitochondrial quality control and the microphthalmia/transcription factor E (MiTF/TFE) family -- Introduction -- The lay of the land: mitophagy players -- Mitochondrial malfunction -- AMPK, the puppet master -- Regulation of autophagy by AMPK -- Lysosomal biogenesis: planning ahead -- AMPK and communication between mitochondria and lysosomes -- TFEB regulation -- TFEB and autophagy -- TFEB and mitophagy -- TFEB and mitochondrial biogenesis -- Concluding remarks -- References -- 16 Cardioprotection through mitophagy. | |
| 650 | 0 | |a Homeostasis. | |
| 650 | 6 | |a Homéostasie. |0 (CaQQLa)201-0022624 | |
| 650 | 7 | |a Homeostasis |2 fast |0 (OCoLC)fst00959606 | |
| 700 | 1 | |a Lemasters, John J., |e editor. | |
| 856 | 4 | 0 | |3 ScienceDirect |u https://www.sciencedirect.com/science/book/9780443152603 |