Advances in cancer biomarkers research /
Advances in Cancer Biomarkers Research provides a thorough and detailed description of cancer biomarkers for diagnostic, prognostic and therapeutics in several cancer types. The book presents a compendium of topics related to current advanced research, along with fundamental knowledge that will help...
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| Бусад зохиолчид: | , , |
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| Формат: | Цахим Цахим ном |
| Хэл сонгох: | англи |
| Хэвлэсэн: |
London, United Kingdom ; San Diego, CA, United States ; Cambridge, MA, United States :
Elsevier, Academic Press, an Imprint of Elsevier,
[2025]
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| Нөхцлүүд: | |
| Онлайн хандалт: | ScienceDirect |
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| 003 | OCoLC | ||
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| 020 | |a 9780323952590 |q (electronic book) | ||
| 020 | |a 0323952593 |q (electronic book) | ||
| 020 | |z 9780323952583 | ||
| 035 | |a (OCoLC)1479454755 | ||
| 050 | 4 | |a RC268.4 | |
| 082 | 0 | 4 | |a 616.99/4042 |2 23/eng/20241216 |1 https://id.oclc.org/worldcat/ddc/E3rBPFBQWdKBDxrgtgxfQH6GKt |
| 245 | 0 | 0 | |a Advances in cancer biomarkers research / |c edited by Anand Narayan Singh, Rashmi Rana, Seema Nayak. |
| 264 | 1 | |a London, United Kingdom ; |a San Diego, CA, United States ; |a Cambridge, MA, United States : |b Elsevier, Academic Press, an Imprint of Elsevier, |c [2025] | |
| 264 | 4 | |c ©2025 | |
| 300 | |a 1 online resource. | ||
| 336 | |a text |b txt |2 rdacontent | ||
| 337 | |a computer |b c |2 rdamedia | ||
| 338 | |a online resource |b cr |2 rdacarrier | ||
| 347 | |a text file |2 rdaft | ||
| 353 | |a bibliography |b bibliography |0 http://id.loc.gov/vocabulary/msupplcont/bibliography | ||
| 353 | |a index |b index |0 http://id.loc.gov/vocabulary/msupplcont/index | ||
| 504 | |a Includes bibliographical references and index. | ||
| 520 | |a Advances in Cancer Biomarkers Research provides a thorough and detailed description of cancer biomarkers for diagnostic, prognostic and therapeutics in several cancer types. The book presents a compendium of topics related to current advanced research, along with fundamental knowledge that will help readers fully comprehend the field of cancer biomarkers. Topics discussed include such the role of genetic mechanisms, epigenetics, DNA and microRNA in different cancers, signaling pathways and exosomes. In addition, the book discusses biomarker research applied to several cancer types, such as head and neck, urological, lung, bone tumors, hematological and neurological malignancies and breast cancers.This will be a valuable resource for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in the potential of biomarkers in cancer research and treatment. | ||
| 588 | 0 | |a Online resource; title from PDF title page (ScienceDirect, viewed December 16, 2024). | |
| 505 | 0 | |a Front Cover -- Advances in Cancer Biomarkers Research -- Copyright Page -- Contents -- List of contributors -- 1 Emerging role of biomarker in different cancers -- 1.1 Introduction -- 1.2 Categories of biomarkers: Generally five categories of biomarkers -- 1.3 Biomarkers classification: Biomarkers are classified in following groups -- 1.4 Biomarkers signatures -- 1.4.1 Following are signature of biomolecules -- 1.5 Types of tumor biomarkers -- 1.6 Diagnostic markers are basically two types -- 1.6.1 Prognostic marker -- 1.6.2 Predictive marker -- 1.7 Uses of tumor biomarkers -- 1.7.1 Characteristic of ideal tumor marker -- 1.7.2 Potential biomarkers in peripheral blood for immune response -- 1.8 Techniques for analyzing biomarkers -- 1.8.1 DNA and RNA based -- 1.8.1.1 Polymerase chain reaction -- 1.8.1.2 In situ hybridization -- 1.8.1.3 Next generation sequencing -- 1.8.1.4 Pyrosequencing -- 1.9 Protein based -- 1.9.1 Immunohistochemistry -- 1.10 Molecular pathways in tumor development -- 1.10.1 TP53/RB pathway -- 1.10.2 NOTCH pathway -- 1.10.3 JAK/STAT pathway -- 1.10.4 RAS/RAF/MAPK pathway -- 1.10.5 PI3K/Akt/mTOR pathway -- 1.10.6 Epidermal growth factor receptor pathway -- 1.10.7 MET pathway -- 1.11 Biomarkers in different cancers: comprehensive compilation of biomarkers in different cancers are describe in Table 1.1 -- 1.11.1 Biomarkers from brain tumors -- 1.11.2 Biomarkers for head and neck cancer -- 1.11.3 Biomarkers for breast cancer -- 1.11.4 Biomarkers for sarcomas -- 1.11.5 Biomarkers for lung cancer -- 1.11.6 Biomarker for colorectal carcinoma -- 1.11.7 Biomarkers for prostate carcinoma -- 1.11.8 Biomarkers for female genital organs cancer -- 1.11.9 Biomarkers for lymphoma and leukaemia -- 1.12 Conclusion -- References -- 2 Role of genetic mechanism in cancer -- 2.1 Introduction -- 2.2 DNA repair mechanism in cancer. | |
| 505 | 8 | |a 2.3 Molecules involved for the DNA damage response -- 2.4 Genetic mechanism of cancer -- 2.5 Oncogenes -- 2.6 Oncogene types and classification -- 2.7 The role of oncogenes in anticancer therapy -- 2.8 p53 Tumor suppressor gene -- 2.9 Noncoding RNAs in cancer -- 2.10 Role of microRNA in cancer -- 2.11 Therapeutics in cancer -- 2.12 Chemotherapy -- 2.13 Radiotherapy -- 2.14 Combined radiotherapy and chemotherapy -- 2.15 Combined radiotherapy and immunotherapy -- 2.16 Surgical approach -- 2.17 Targeted therapies -- 2.18 Conclusion -- References -- 3 Role of epigenetics, DNA methylation, histone modification, and microRNA in different cancers -- 3.1 Introduction -- 3.1.1 Epigenetic mechanisms -- 3.1.2 DNA methylation -- 3.1.3 Histone modification -- 3.1.4 MicroRNAs -- 3.1.5 Epigenetic abnormalities in tumorigenesis and development -- 3.1.5.1 Breast cancer -- 3.1.5.2 Prostate cancer -- 3.1.5.3 Lung cancer -- 3.1.5.4 Colon cancer -- 3.1.6 Epigenetic therapy and future challenges -- References -- 4 Biogenesis of extracellular vesicles and their role in cancer -- 4.1 Introduction -- 4.2 Extracellular vesicles classes, biogenesis, and composition -- 4.3 Biogenesis of extracellular vesicles -- 4.3.1 Microvesicle biogenesis -- 4.3.2 Exosome biogenesis -- 4.3.3 Apoptotic bodies biogenesis -- 4.4 Tumor microenvironment -- 4.5 Extracellular vesicles in the microenvironment -- 4.6 Extracellular vesicles and cancer progression -- 4.6.1 Extracellular vesicles mediate cancer cell phenotypes -- 4.7 Extracellular vesicles and tumor angiogenesis -- 4.8 Extracellular vesicles and metastasis -- 4.9 Extracellular vesicles and cancer-mediated immunosuppression -- 4.10 Clinical utility of extracellular vesicles -- 4.11 Extracellular vesicles as biomarkers -- 4.12 Extracellular vesicles in drug resistance -- 4.13 Extracellular vesicles as cancer therapeutic. | |
| 505 | 8 | |a 5.16 Alternative pathways after signal disruption -- 5.16.1 Epigenetics pathway -- 5.17 Conclusion -- Abbreviations -- References -- 6 Theragnostic exosomes in cancer -- 6.1 Introduction -- 6.2 Structure and composition of exosomes -- 6.2.1 Biogenesis of exosomes -- 6.2.2 Isolation of exosomes -- 6.2.2.1 Ultracentrifugation techniques -- 6.2.2.2 Size-based techniques -- 6.2.2.3 Capture-based techniques -- 6.2.2.4 Precipitation techniques -- 6.2.2.5 Microfluidic-based techniques -- 6.3 Theragnostics applications -- 6.3.1 Exosomes in therapeutics -- 6.3.1.1 Drug delivery -- 6.3.1.2 Antigen delivery -- 6.3.2 Exosomes in diagnosis -- 6.3.2.1 Imaging of exosomes -- 6.3.2.2 Exosome as biomarkers -- 6.3.3 Translational application -- References -- 7 Exosomes: current and novel biomarkers tools for early stage diagnosis of cancer -- 7.1 Introduction -- 7.1.1 Functions of exosomes -- 7.2 Oncologic characterization of exosomes -- 7.2.1 Exosome composition -- 7.2.2 Exosome-mediated intercellular communication -- 7.3 Exosomes as diagnostic and predictive biomarkers for cancer -- 7.3.1 Nucleic acids in cancer exosomes -- 7.3.1.1 Exosomal noncoding RNAs/microRNAs -- 7.3.1.2 Exosomal circRNAs -- 7.3.2 Proteins in cancer exosomes -- 7.3.3 Hypoxia -- 7.4 Exosomes in different cancer -- 7.5 Conclusion -- 7.6 Future perspective -- References -- 8 Genetic, epigenetic and exosomal biomarkers in neurological malignancies -- 8.1 Introduction -- 8.2 Neurological malignancies: an overview -- 8.2.1 Primary brain tumors -- 8.2.2 Secondary brain tumors -- 8.3 Biomarkers: conceptual analysis -- 8.4 Genetic biomarkers in neurological malignancies -- 8.5 Epigenetic biomarkers in neurological malignancies -- 8.6 Histone modifications and mutations -- 8.7 DNA methylation -- 8.8 MicroRNAs -- 8.9 Long noncoding RNAs -- 8.10 Exosomal biomarkers in neurological malignancies. | |
| 505 | 8 | |a 8.11 Challenges of biomarkers -- 8.12 Future prospects and conclusion -- References -- 9 Current epigenetic and exosomal biomarkers in head and neck cancers -- 9.1 Introduction -- 9.2 Genetic alterations -- 9.3 Epigenetic alterations -- 9.4 Promoter hypermethylation -- 9.5 MicroRNAs (miRNAs) and small interfering RNA (siRNA) -- 9.6 Histone acetylation -- 9.7 Exosomes as emerging biomarker in head and neck cancer -- 9.8 Biogenesis of exosomes -- 9.9 Isolation of exosomes -- 9.10 Structure of exosomes -- 9.11 Potential diagnostic and therapeutic applications of exosomes on HNSCC -- 9.11.1 Diagnostic approach -- 9.11.2 Therapeutic approach -- 9.11.3 Immune modulation -- 9.11.4 Exosomes as targeted drug delivery -- 9.11.5 Ongoing clinical trial with exosomes in HNCC -- 9.12 Conclusion -- References -- 10 Role of epigenetics in breast cancer: current status and future perspectives -- 10.1 Introduction -- 10.1.1 Types and molecular profiling of breast cancer -- 10.2 Role of epigenetics in breast cancer -- 10.2.1 Alterations of breast cancer epigenome -- 10.2.1.1 DNA methylation -- 10.2.2 Histone modifications -- 10.2.3 MicroRNAs -- 10.2.4 Alterations as tumor microenvironment in breast cancer -- 10.3 Methods for detection of epigenetic changes -- 10.4 Epigenetics as biomarkers -- 10.4.1 Epigenetics as diagnostic and prognostic biomarkers -- 10.4.2 Epigenetics as predictive biomarkers -- 10.5 Epigenetics in breast cancer treatment -- 10.5.1 Epidrugs -- 10.6 Future perspective -- 10.7 Conclusion -- AI disclosure -- References -- 11 Role of extracellular vesicles in renal cell carcinoma -- 11.1 Introduction -- 11.2 Extracellular vesicles: what's more to these cell mediators? -- 11.3 Extracellular vesicles biogenesis and secretion -- 11.4 Extracellular vesicles in renal cell carcinoma -- 11.5 Immune evasion -- 11.6 Tumorigenesis -- 11.7 Tumor metastasis. | |
| 650 | 0 | |a Cancer |x Genetic aspects. | |
| 650 | 0 | |a Cancer |x Molecular aspects. | |
| 650 | 0 | |a Biochemical markers. | |
| 650 | 2 | |a Biomarkers |0 (DNLM)D015415 | |
| 650 | 6 | |a Cancer |x Aspect génétique. |0 (CaQQLa)201-0004687 | |
| 650 | 6 | |a Cancer |x Aspect moléculaire. |0 (CaQQLa)201-0212614 | |
| 650 | 6 | |a Marqueurs biologiques. |0 (CaQQLa)201-0177920 | |
| 650 | 7 | |a Biochemical markers |2 fast |0 (OCoLC)fst00831950 | |
| 650 | 7 | |a Cancer |x Genetic aspects |2 fast |0 (OCoLC)fst00845368 | |
| 650 | 7 | |a Cancer |x Molecular aspects |2 fast |0 (OCoLC)fst00845397 | |
| 700 | 1 | |a Singh, Anand Narayan, |e editor. | |
| 700 | 1 | |a Nayak, Seema, |e editor. | |
| 700 | 1 | |a Rana, Rashmi, |e editor. | |
| 776 | 0 | 8 | |i Print version: |t Advances in cancer biomarkers research. |d London, United Kingdom ; San Diego, CA, United States ; Cambridge, MA, United States : Elsevier, Academic Press, an Imprint of Elsevier, [2025] |z 9780323952583 |
| 856 | 4 | 0 | |3 ScienceDirect |u https://www.sciencedirect.com/science/book/9780323952583 |